Design of Four-Component Protein Nanocages through Programmed Symmetry Breaking Academic Background Protein nanocages are highly symmetric protein assemblies widely used in vaccine development, drug delivery, and nanomaterial design. In nature, viruses often construct complex structures through symmetry breaking, particularly in high triangulation ...

The Respiratory Microbiome is Linked to the Severity of RSV Infections and the Persistence of Symptoms in Children Academic Background Respiratory Syncytial Virus (RSV) is a leading cause of respiratory infections and hospitalizations in infants. While known risk factors for severe infections include preterm birth, congenital heart disease, and bro...

The Ongoing Evolution of SARS-CoV-2 Drives Escape from mRNA Vaccine-Induced Humoral Immunity Academic Background Since its emergence in late 2019, SARS-CoV-2 has undergone continuous evolution, giving rise to multiple variants. These variants have enhanced their transmissibility and immune evasion capabilities through mutations, particularly agains...

Report on the Academic Paper Paper Source The paper, titled “Modulation of TCR Stimulation and Pifithrin-α Improves the Genomic Safety Profile of CRISPR-Engineered Human T Cells,” was authored by Laurenz T. Ursch, Jule S. Müschen, Julia Ritter, and others from institutions such as the Technical University of Munich and the University of Freiburg Me...

Academic Background The tumor microenvironment (TME) is a critical area in cancer research, where tumor cells interact with surrounding non-tumor cells to influence disease progression and therapeutic responses. Tumor-associated macrophages (TAMs) play a pivotal role in tumor growth, angiogenesis, and immune suppression. Recently, the role of metab...