A Glucocorticoid Spike Derails Muscle Repair to Heterotopic Ossification After Spinal Cord Injury

A Glucocorticoid Spike Derails Muscle Repair to Heterotopic Ossification After Spinal Cord Injury

Academic Background and Problem Statement Neurogenic Heterotopic Ossification (NHO) is a pathological condition where ectopic bone tissue forms in muscles following severe central nervous system (CNS) injuries, such as spinal cord injury (SCI), traumatic brain injury (TBI), or stroke. NHO not only impairs motor function but can also lead to joint s...

Cycling Alpha Cells in Regenerative Drug-Treated Human Pancreatic Islets May Serve as Key Beta Cell Progenitors

Academic Background Diabetes is a global health issue affecting over 500 million people. Both type 1 diabetes (T1D) and type 2 diabetes (T2D) share the common feature of a significant reduction in the number of functional insulin-secreting beta cells. Therefore, restoring or increasing beta cell mass is considered a key strategy in diabetes treatme...

Inferring Phase Transitions and Critical Exponents from Limited Observations with Thermodynamic Maps

Inferring Phase Transitions and Critical Exponents from Limited Observations with Thermodynamic Maps Academic Background Phase transitions are ubiquitous phenomena in nature, ranging from the boiling of water to the ferromagnetic-paramagnetic transition in magnetic materials, and even to conformational changes in biomolecules such as proteins and n...

Toward Systems Agroecology: Design and Control of Intercropping

Toward Systems Agroecology: Design and Control of Intercropping Academic Background With changing climatic conditions and the gradual depletion of natural resources such as fertile soil and water, exploring alternatives to today’s industrial monocrop farming has become essential. Intercropping (IC), a promising agricultural practice, involves growi...

MINFLUX Fluorescence Nanoscopy in Biological Tissue

MINFLUX Fluorescence Nanoscopy in Biological Tissue

MINFLUX Nanoscopy in Biological Tissue: Breaking the Resolution Barrier of Fluorescence Microscopy Academic Background Fluorescence microscopy plays a crucial role in biological research, but its resolution is limited by the diffraction barrier, typically around 200 nanometers. In recent years, the development of super-resolution microscopy (SR) te...