Academic Background Neuroscience research has made significant progress over the past decade, particularly in the development of neurotechnologies and genetic tools for dissecting neural circuit functions. However, the advancement of neuropharmacological methodologies has lagged in comparison. Understanding the precise pharmacological mechanisms of...

Academic Background Sleep plays a crucial role in memory formation, particularly non-rapid eye movement (NREM) sleep, which is considered a critical stage for memory consolidation. However, the specific mechanisms underlying memory consolidation, especially how intracellular signaling molecules coordinate with neural activity, remain a mystery. Cyc...

Academic Background Stroke is one of the leading causes of adult disability globally, with the core issue being neuronal damage and neurological dysfunction. Although neurogenesis and neurorepair after stroke are considered crucial for recovery, the specific mechanisms remain incompletely understood. Recent studies have shown that immune cells play...

Academic Background TDP-43 (TAR DNA-binding protein 43) is an RNA-binding protein primarily located in the nucleus, involved in multiple processes of RNA metabolism, including transcription, splicing, RNA transport, and translation. However, in various neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementi...

Alzheimer’s Disease (AD) is the most common form of dementia, characterized by the accumulation of amyloid-beta (Aβ) plaques and neurofibrillary tangles (NFTs) in the brain, leading to the progressive deterioration of brain function. Although Aβ plaques and NFTs have long been considered hallmarks of AD pathology, therapeutic strategies targeting t...