Optimized Phenotyping of Complex Morphological Traits: Enhancing Discovery of Common and Rare Genetic Variants

1. Academic Background and Research Motivation In recent years, genotype–phenotype (G-P) association analysis has become a core means of revealing the genetic basis of complex traits, especially with rapid development in the study of multidimensional structural traits such as the human face, limbs, and skeleton. Traditionally, G-P analyses rely on ...

Cancer Gene Identification through Integrating Causal Prompting Large Language Model with Omics Data–Driven Causal Inference

Cancer gene identification is a core challenge in the fields of basic cancer research and precision medicine. Recently, a research team from Jilin University and Zhejiang Sci-Tech University published an original study titled “Cancer gene identification through integrating causal prompting large language model with omics data–driven causal inferenc...

Testing and Overcoming the Limitations of Modular Response Analysis

Research Background: New Challenges in Network Inference In the fields of modern molecular biology and systems biology, the precise elucidation of biomolecular networks—such as gene regulatory networks, protein interaction networks, and signaling networks—is regarded as central to understanding cellular processes, disease mechanisms, and drug actio...

DockEM: An Enhanced Method for Atomic-Scale Protein–Ligand Docking Refinement Leveraging Low-to-Medium Resolution Cryo-EM Density Maps

Academic Background and Research Motivation In recent years, protein–ligand docking has rapidly developed as a core technology for virtual drug screening and structure-based drug discovery. Despite improvements in drug discovery efficiency through large-scale high-throughput screening technologies, new drug development still faces high costs, long ...

Exploring Diverse Approaches for Predicting Interferon-Gamma Release: Utilizing MHC Class II and Peptide Sequences

Academic Background and Research Significance In recent decades, therapeutic proteins have gained prominence as a research focus in the biopharmaceutical industry due to their huge potential in medicine. With their high targeting ability, therapeutic protein drugs are considered to offer solutions for many acute or chronic diseases (such as certain...