Regularly Updated Benchmark Sets for Statistically Correct Evaluations of AlphaFold Applications

Academic Background: Crossing into a New Era of Protein Structure Prediction Protein structure determination has long stood as one of the central challenges in molecular biology and life sciences. Traditional experimental methods such as X-ray crystallography, nuclear magnetic resonance (NMR), and cryo-electron microscopy have provided a solid foun...

Consensus Statement on the Credibility Assessment of Machine Learning Predictors

1. Background: Machine Learning in Medicine and the Challenge of Credibility In recent years, the rapid development of Artificial Intelligence (AI) and Machine Learning (ML) technologies has brought about a tremendous transformation in the field of healthcare. Particularly in in silico medicine, machine learning predictors have become vital tools f...

Beyond Natural Synthesis via Solar-Decoupled Biohybrid Photosynthetic System

Beyond Natural Synthesis via Solar-Decoupled Biohybrid Photosynthetic System

Academic Background Photosynthetic microorganisms can directly convert carbon dioxide (CO₂) into high value-added long-chain chemicals by converting solar energy into chemical energy, providing a promising route for CO₂ sequestration and sustainable development. However, the key reducing power generated in photosynthetic reactions—nicotinamide aden...

Antigen Spatial-Matching Polyaptamer Nanostructure to Block Coronavirus Infection and Alleviate Inflammation

Academic Background In recent years, multiple outbreaks caused by coronaviruses have occurred globally, such as SARS (Severe Acute Respiratory Syndrome), MERS (Middle East Respiratory Syndrome), and COVID-19 (Novel Coronavirus Pneumonia). These pandemics have not only posed a serious threat to human health but also exposed the inadequacy of emergen...

Cluster-Based Redox-Responsive Super-Atomic MRI Contrast Agents

Academic Background Magnetic Resonance Imaging (MRI) is a crucial tool in modern medical diagnostics, and its effectiveness relies heavily on the use of contrast agents (CAs). Traditional MRI contrast agents are mainly based on gadolinium (Gd) complexes. Although these agents are widely used in clinical practice, their long-term safety is controver...