Endothelial Cells Stably Infected with Recombinant Kaposi’s Sarcoma-Associated Herpesvirus Display Distinct Viscoelastic and Morphological Properties

Kaposi’s sarcoma-associated herpesvirus (KSHV) is a γ-herpesvirus that primarily infects endothelial cells and leads to the development of Kaposi’s sarcoma (KS), especially in people living with HIV. Kaposi’s sarcoma is a malignant tumor characterized by endothelial cell proliferation, typically presenting as cutaneous lesions. After infecting endo...

Development of a Method for Visualizing and Quantifying Thrombus Formation in Extracorporeal Membrane Oxygenators

Extracorporeal Membrane Oxygenation (ECMO) is a life-support technology used for patients with cardiac and respiratory failure. Although ECMO plays a crucial role in clinical practice, its use is accompanied by significant risks of medical device-associated thrombosis. Thrombosis not only obstructs blood flow in the oxygenator but also reduces gas ...

Acteoside-Loaded Self-Healing Hydrogel Enhances Skin Wound Healing through Modulation of Hair Follicle Stem Cells

Skin wound healing is a complex biological process involving the coordination of cellular, molecular, and physiological events. Although traditional treatment methods can promote wound closure to some extent, their efficacy is often unsatisfactory in chronic wounds or complex trauma environments, particularly in controlling infections and inflammat...

High-Throughput Metabolomic Profiling of Skin Lesions: Comparative Study of Cutaneous Squamous Cell Carcinoma, Basal Cell Carcinoma, and Normal Skin via E-Biopsy Sampling

Academic Background Cutaneous Squamous Cell Carcinoma (CSCC) and Basal Cell Carcinoma (BCC) are among the most common types of skin cancer globally. Although the mortality rates of these cancers are relatively low, their incidence has been increasing year by year, significantly impacting patients’ quality of life and potentially leading to prematur...

CRISPR-dCas9 Activation of TSG-6 in MSCs Modulates the Cargo of MSC-Derived Extracellular Vesicles and Attenuates Inflammatory Responses in Human Intervertebral Disc Cells In Vitro

Intervertebral Disc Degeneration (IVDD) is one of the leading causes of low back pain worldwide, significantly impacting patients’ quality of life. IVDD is often accompanied by inflammatory responses, leading to the degradation of the extracellular matrix (ECM) and structural damage. Although cell therapies, such as mesenchymal stem cells (MSCs), h...