Hypoxic Preconditioned ADSC Exosomes Enhance Vaginal Wound Healing via Accelerated Keratinocyte Proliferation and Migration through Akt/HIF-1α Axis Activation

Vaginal wound healing is a critical issue in gynecological surgery, especially following vaginal delivery or pelvic reconstructive surgery. Infection and poor healing of vaginal wounds can lead to severe complications such as chronic pain, infection, and dysfunction. Therefore, accelerating vaginal wound healing has been a focal point of clinical r...

Gene Selection for Single Cell RNA-seq Data via Fuzzy Rough Iterative Computation Model

Background Introduction Single-cell RNA sequencing (scRNA-seq) technology has been widely applied in biomedical research in recent years, as it can reveal the heterogeneity of gene expression at the single-cell level, providing an important tool for understanding cell types, cell states, and disease mechanisms. However, scRNA-seq data is characteri...

Certifying the Sustainability of Herding Practices in Mongolia

Background Introduction Globally, unsustainable agricultural practices have led to ecosystem degradation, particularly the destruction of grassland ecosystems due to overgrazing. Mongolia, as the world’s second-largest producer of cashmere, has significant economic, cultural, and ecological impacts from its nomadic herding practices. However, with ...

Alarming Patterns of Mature Forest Loss in the Brazilian Atlantic Forest

Academic Background The Brazilian Atlantic Forest is one of the world’s biodiversity hotspots, harboring a high number of endemic species and providing critical ecosystem services. However, a long history of deforestation has reduced its original forest cover to just 24%. Despite existing legal protections, the rate of forest loss remains alarming....

Microbiome Dysbiosis, Neutrophil Recruitment and Mesenchymal Transition of Mesothelial Cells Promotes Peritoneal Metastasis of Colorectal Cancer

Background Introduction Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide, with high incidence and mortality rates. According to statistics, approximately 1.87 million new cases of CRC were diagnosed globally in 2020, resulting in 915,000 deaths. Peritoneal metastasis (PM) is a common metastatic pathway of CRC, with about ...