Glutamate Dehydrogenase 1-Catalytic Glutaminolysis Feedback Activates EGFR/PI3K/AKT Pathway and Reprograms Glioblastoma Metabolism

Academic Background Glioblastoma (GBM) is one of the most aggressive and heterogeneous central nervous system tumors, with an extremely poor prognosis. Despite the emergence of novel therapies such as anti-angiogenic treatments and immunotherapy in recent years, the survival period of GBM patients remains very limited. GBM cells exhibit unique meta...

EVA1-Antibody Drug Conjugate as a Novel Therapeutic Strategy for Eliminating Glioblastoma-Initiating Cells

Background Introduction Glioblastoma (GBM) is one of the most aggressive brain cancers, with a median survival of approximately 15 months. Despite the use of multimodal treatments including surgery, chemotherapy, and radiotherapy, the overall survival rate of GBM patients has not significantly improved over the past few decades. Recent studies have...

Clinical and Genetic Markers of Vascular Toxicity in Glioblastoma Patients: Insights from NRG Oncology RTOG-0825

Clinical and Genetic Markers of Vascular Toxicity in Glioblastoma Patients: Insights from NRG Oncology RTOG-0825 Academic Background Glioblastoma (GBM) is a highly aggressive form of brain cancer, accounting for nearly 80% of malignant primary brain tumors. Despite standard treatments including surgical resection, radiotherapy, and chemotherapy, th...

Anxiety Disorder Identification with Biomarker Detection through Subspace-Enhanced Hypergraph Neural Network

Anxiety Disorder Identification with Biomarker Detection through Subspace-Enhanced Hypergraph Neural Network

Anxiety Disorder Identification and Biomarker Detection Based on Subspace-Enhanced Hypergraph Neural Network Academic Background Anxiety Disorders (ADs) are prevalent mental health issues globally, affecting approximately 7.3% of the population. Patients with anxiety disorders typically exhibit excessive fear, worry, and related behavioral abnormal...

The Influence of Double Delays in a Diffusive Predator–Prey System: Stability Switching Curves Method

The Influence of Double Delays in a Diffusive Predator-Prey System: A Study Using the Stability Switching Curve Method Academic Background The predator-prey model is one of the fundamental models in ecology for studying population interactions. Although these models may seem simple, they can generate complex dynamic structures and even lead to chao...