High-precision Base Editing Technology in Primates and Human Retina Research Background Stargardt disease is a currently untreatable, inherited neurodegenerative disease that leads to macular degeneration and blindness due to loss-of-function mutations in the ABCA4 gene. The protein encoded by the ABCA4 gene is a membrane lipid flippase localized i...

The Role of Major Cardiovascular Surgery-Induced Metabolic Reprogramming in Acute Kidney Injury: A Metabolomics Study Academic Background Cardiovascular diseases are the leading cause of death worldwide, accounting for over 17.9 million deaths annually, which is 32% of all deaths. As the disease burden increases, about one-third of patients may req...

A Prediction Model for Invasive Pulmonary Aspergillosis in Immunocompromised Patients with Acute Respiratory Failure Background Introduction Invasive Pulmonary Aspergillosis (IPA) is a severe opportunistic infection commonly seen in immunocompromised patients, particularly those with immune dysfunction caused by hematological malignancies, stem cel...

Academic Background The regenerative capacity of the nervous system varies significantly between different regions. Axons in the peripheral nervous system (PNS) can regenerate spontaneously after injury, whereas axons in the central nervous system (CNS) lack this ability. This difference makes recovery after CNS injury extremely challenging, especi...

Academic Background The field of neuroscience has long been dedicated to understanding how neural circuits generate and control complex behaviors. Although simple model organisms, such as mollusks, crustaceans, and annelids, have provided valuable models for research due to their accessible nervous systems and large characteristic neurons, in many ...