Development of a Novel Molecular Probe for Visualizing Mesothelin in Tumors

Development of a Molecular Probe for Tumor-Associated Protein Mesothelin Based on PET Imaging Technology Research Background In recent years, mesothelin (MSLN) has become a key focus in cancer research and diagnostics. Mesothelin is a membrane-bound glycoprotein highly expressed on the surface of various malignancies, including ovarian, pancreatic,...

Transcriptionally Downregulated GABAergic Genes Associated with Synaptic Density Network Dysfunction in Temporal Lobe Epilepsy

Revealing Gene Expression Patterns Associated with Synaptic Density Network Dysfunction in Temporal Lobe Epilepsy Background Temporal Lobe Epilepsy (TLE) is the most common form of focal epilepsy, and its pathological features and mechanisms have long drawn extensive attention in the field of neuroscience. This disorder involves not only a single b...

Overexpression of REF-1 in Neovascular Eye Diseases and Its Inhibition by a Novel Compound

REF-1 Overexpression in Neovascular Eye Diseases and Therapeutic Targeting with a Novel Inhibitor Academic Background Neovascular age-related macular degeneration (nAMD) is a common blinding eye disease predominantly affecting individuals aged 60 years and older. nAMD is characterized by the formation of subretinal neovascularization, leading to re...

Prediction of Monocular Defocus Curves in Pseudophakia with Different Pupil Sizes

Background With the widespread adoption of cataract surgery and lens replacement surgery, the optical performance of intraocular lenses (IOLs) has become increasingly critical in determining patients’ postoperative visual quality. Predicting clinical visual performance (such as visual acuity and defocus range) is an emerging area of interest in oph...

Three-Dimensional Monitoring of RBC Sedimentation in External Magnetic Fields

Study on Three-Dimensional Monitoring of Red Blood Cell Sedimentation under External Magnetic Fields: A Novel Scientific Perspective Background and Research Objective With the widespread use of electronic devices in modern society, humans are increasingly exposed to external magnetic fields (MFs) in their living environments. However, the potential...