Decoding the Human Vascular System: A Comprehensive Multi-organ Single-cell Transcriptomic Study Reveals Vascular Cell Diversity Background Overview The human vascular system is a core component for sustaining life, comprising endothelial cells (ECs) and mural cells that span across all organ systems. Its functions extend beyond merely delivering b...

Gene Expression Dynamics During Human Brain Maturation: A Novel Temporal Cortex Cell Atlas Academic Background The development and maturation of the human brain are critical areas in neuroscience, though many mysteries remain unresolved. Guided by changes in gene expression, the human brain undergoes a prolonged and complex postnatal maturation pro...

Single-cell RNA Sequencing Reveals Cell-type-specific Splicing Regulation in Peripheral Blood Linked to Autoimmune and Inflammatory Diseases Background In recent years, rapid advancements in genomics research have provided deeper insights into the genetic basis of complex traits. However, the functional mechanisms underlying most disease-associated...

A New Method for Scalable Spatial Transcriptomics via Large-Format Microarrays: The Birth of Array-Seq Technology Background and Research Motivation In recent years, spatiomolecular analyses have become pivotal tools in biomedical research and clinical pathology due to their ability to study how the spatial organization of cells and molecules withi...

A New Platform for Efficient Signal Amplification of Nucleic Acid Targets in Tissue and Clinical Research: PSABER Background and Related Knowledge Since its first introduction by Pardue and Gall in the 1960s, in situ hybridization (ISH) has been widely adopted in research and clinical applications for its ability to spatially map nucleic acid targe...