The 5’ untranslated region (5’UTR) is a regulatory region at the start of messenger RNA (mRNA) molecules, playing a crucial role in regulating the translation process and affecting protein expression levels. Language models have demonstrated effectiveness in decoding protein and genomic sequence functions. In this study, the authors introduce a lan...

Overcoming Acquired Resistance in Colorectal Cancer by Targeting LGR4 Research Background: Acquired drug resistance is a major obstacle in cancer treatment and a leading cause of cancer-related deaths. However, the mechanisms of resistance are diverse, and how to specifically target resistant cancer cells remains a significant clinical challenge. A...

This paper reports on research investigating how zebra finches recover their complex learned behaviors following large-scale neuronal perturbations. The researchers selectively disrupted the activity of the projection neurons in the HVC (hyperpallium ventralis) region critical for song sequence generation in zebra finches using genetic tools, leadi...

This paper reports a study on the cognitive representation of intracranial self-stimulation (ICSS) of midbrain dopamine neurons. The authors aimed to answer why rats work to obtain ICSS, i.e., how the pulsatile activation of dopamine neurons is represented in the brain. Research Background: The pulsatile activation of dopamine neurons is typically ...

I. Research Background and Purpose The subcommissural organ (SCO) is a glandular structure located at the entrance of the ventricular system, which is present in humans and other vertebrates, but its function has not been fully elucidated. Previous studies have suggested that the SCO may be involved in the regulation of neural development and the m...

Single-cell sequencing technology reveals unique splicing patterns in developing and adult mouse and human brains In the nervous system, the splicing patterns of messenger RNA (mRNA) play a critical role in establishing cellular identity and regulating cellular functions. However, a comprehensive atlas depicting the mRNA splicing patterns across br...