Report on the Study of Bacterial Toxins Inducing Non-Canonical Migracytosis and Aggravating Acute Inflammation Background and Research Objectives In recent years, the discovery of migrasomes, a new type of membrane structure, has gained significant attention in the scientific community for its role in cell migration and various biological functions...
Stem Cell Transplantation Extends the Reproductive Lifespan of Naturally Aging Cynomolgus Monkeys Background of the Study The ovary is a crucial organ for female reproduction and health, responsible for producing oocytes and secreting sex hormones. As women age, ovarian reserves gradually decline, eventually leading to menopause, which brings about...
Study of Somite Formation Model Based on Microfluidic System Background and Research Motivation The formation of somites plays a crucial role in vertebrate embryonic development, significantly influencing the layout and functionality of the embryonic musculoskeletal system. Somite formation involves the segmentation of bilateral presomitic mesoderm...
Metabolic and Epigenetic States of HSC-Derived Macrophages in Autoimmune Diseases and Their Driving Mechanism of Trained Immunity Research Background In the context of autoimmune diseases (AD), studies have shown that prolonged activation of the immune system and inflammatory responses affect not only mature immune cells but also have profound effe...
Background Since the outbreak of the COVID-19 pandemic, SARS-CoV-2 infection has not only affected the respiratory system but has also been closely related to metabolic diseases such as diabetes. Clinical observations have found occurrences of new-onset diabetes and worsening of existing diabetes among COVID-19 patients, particularly with an increa...
Modeling the Atrioventricular Conduction Axis Based on Human Pluripotent Stem Cell-Derived Cardiac Assembloids Research Background The atrioventricular (AV) conduction axis is responsible for electrical conduction between the atrium and the ventricle and is a core component of the cardiac electrophysiological system. The delay function of AV conduc...