The Relationship Between Cancer Risk and Epigenetic Age Acceleration After Stroke

Medicine, Environmental and Public Health, Basic Medical Sciences, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
stroke   cancer risk   epigenetic clock   DNA methylation   biological age acceleration  

Study on the Association Between Long-Term Cancer Risk and Epigenetic Age in Stroke Survivors Background and Significance Cancer and stroke are leading global causes of morbidity and mortality, with their association being increasingly recognized. Statistics show that about 6% of cancer patients experience a stroke during their lifetime, while stro...

Integration of Multi-Omics Data Reveals the Role of Efferocytosis in Lung Adenocarcinoma Prognosis and Immunotherapy

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
lung adenocarcinoma   efferocytosis   single-cell RNA-seq   prognosis   immunotherapy   precision medicine   deep learning  

Research Report on Efferocytosis Features and Their Prognostic and Immunotherapy Associations in Lung Adenocarcinoma Background and Research Motivation Lung cancer is a leading cause of cancer-related mortality worldwide, with lung adenocarcinoma (LUAD) being the most common histological subtype. Due to the insidious nature of the disease and lack ...

Tumor Analysis of BRCA Carriers Reveals Genomic Similarities Despite Temporal Separation

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
BRCA   breast cancer   genomic profile   molecular analysis   early life events   genetic modifiers   preventive medicine  

Tumor Analysis of BRCA1/2 Carriers: Genomic Similarities Evident Across Different Time Points Breast cancer (BC) is the most common malignant tumor among women globally, with its pathogenesis predominantly sporadic, while familial hereditary cases account for only 5% to 10%. Among various pathogenic molecules, mutations in the BRCA1/2 genes (Pathog...

The Role of Radioresistant-Related Telomere Genes in the Prognosis and Immune Infiltration of Lung Adenocarcinoma

Medicine, Respiratory System, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
lung adenocarcinoma   radiotherapy   telomere genes   immune infiltration   prognostic model  

The Impact of Radioresistant-Related Telomere Genes on Prognosis and Immune Infiltration in Lung Adenocarcinoma Lung adenocarcinoma (LUAD), a common subtype of non-small cell lung cancer (NSCLC), has a high incidence and mortality rate. Despite significant progress in early detection and treatment, the overall survival (OS) rate of LUAD patients re...

Multiomic Analysis Identifies Survival Predictors in African American Patients with Acute Myeloid Leukemia

Medicine, Medical Laboratory Science, Hematology, Oncology, Life Sciences, Cell Biology, Immunology, Genetics,
acute myeloid leukemia   African American   gene mutations   inflammation   survival predictors   genomic analysis   multiomic study  

Multi-omics Analysis Reveals Predictors of Survival in African American AML Patients Background and Objectives Acute Myeloid Leukemia (AML) is a hematologic malignancy characterized by clonal expansion of myeloid progenitor cells driven by genomic alterations. Despite advances in genomic profiling, studies focusing on diverse ancestral populations ...

Therapeutic Effects of Combination of Nebivolol and Donepezil: Targeting Multifactorial Mechanisms in ALS

Chemistry, Medicinal Chemistry, Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Amyotrophic Lateral Sclerosis   Neurodegeneration   Multifactorial Mechanisms   Drug Combination Therapy   Motor Neuron Protection  

Report on ALS Treatment Study: Exploring the Multifaceted Mechanisms of Nebivolol and Donepezil Background and Research Objectives Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease marked by progressive loss of motor neurons in the spinal cord and brain, leading to severe muscle atrophy, functional decline, and eventual death...