Research Report: β-Hydroxybutyrate Improves Redox State, Cytokine Secretion, and Phagocytic Ability of Glucose-Deprived HMC3 Human Microglia Introduction Microglia are resident neuroimmune cells in the brain, accounting for 5-12% of total neuroglial cells, with strong migration, proliferation, and phagocytic abilities. For example, microglia mainta...
Repeated Low-Dose Lipopolysaccharide Pretreatment Improves Behavioral Abnormalities and Aberrant Immune Responses Induced by Repeated Social Defeat Stress Background Stress significantly impacts human health, with chronic stress particularly inducing various physiological and psychological disorders. The hypothalamic-pituitary-adrenal (HPA) axis is...
Epigallocatechin-3-Gallate (EGCG) Inhibits Neuroinflammation in BV2 Cells by Regulating the ROS/TXNIP/NLRP3 Pathway Research Background Alzheimer’s Disease (AD) is a degenerative brain disorder primarily affecting the elderly, characterized by persistent cognitive dysfunction and behavioral impairment. The neuropathological changes in AD include β-...
Research Report on the Association between Gene Variants and Neurocognitive Impairment in HIV Patients Over the past few decades, antiretroviral therapy (ART) has greatly improved the health of people infected with human immunodeficiency virus (HIV). However, even with effective viral suppression and partial immune system recovery, up to 50% of Peo...
Research Report on the Mechanism of Glycyrrhizic Acid in Alleviating Neurotoxicity Induced by Semen Strychni Background Introduction Semen Strychni, derived from the dried mature seeds of Strychnos Nux-vomica, has been found to possess various pharmacological activities, including anti-tumor, anti-inflammatory, immunosuppressive, and neuroexcitator...
Overview of the Role of RhoA/ROCK/NF-κB Pathway in Microglial Polarization after Ischemic Stroke In recent years, ischemic stroke has become one of the leading causes of death and disability worldwide. However, effective treatments for ischemic stroke are still lacking. Studies have shown that microglia, as resident macrophages in the central nervo...