The Roles of RhoA/ROCK/NF-κB Pathway in Microglia Polarization Following Ischemic Stroke

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Ischemic Stroke   RhoA/ROCK Pathway   NF-κB   Microglia   Immune Response   Brain Injury   Inflammation  

Overview of the Role of RhoA/ROCK/NF-κB Pathway in Microglial Polarization after Ischemic Stroke In recent years, ischemic stroke has become one of the leading causes of death and disability worldwide. However, effective treatments for ischemic stroke are still lacking. Studies have shown that microglia, as resident macrophages in the central nervo...

JAK1/2 Regulates Synergy Between Interferon Gamma and Lipopolysaccharides in Microglia

Medicine, Rheumatology and Immunology, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
microglia   LPS   interferons   JAK-STAT  

JAK1/2 Regulates the Synergistic Effect Between Interferon γ and Lipopolysaccharide in Microglia A research paper titled “JAK1/2 Regulates the Synergistic Effect Between Interferon γ and Lipopolysaccharide in Microglia” was published in the Journal of Neuroimmune Pharmacology in 2024. This article was completed by scholars Alexander P. Young and Ei...

β-sitosterol alleviates neuropathic pain by affecting microglia polarization through inhibiting tlr4/nf-κb signaling pathway

Medicine, Neurology, Pharmacy, Life Sciences, Cell Biology, Biochemistry, Immunology,
β-sitosterol   tlr4   nf-κb   gmi-r1   inflammation   sciatica  

β-Sitosterol Alleviates Neuropathic Pain by Inhibiting the TLR4/NF-κB Signaling Pathway Background Neuropathic pain is a common and difficult-to-treat chronic pain condition in clinical practice, with complex and not fully understood etiology. Research has shown that neuroinflammation is one of the main causes of chronic neuropathic pain. Microglia...

Doxycycline-loaded calcium phosphate nanoparticles with a pectin coat can ameliorate lipopolysaccharide-induced neuroinflammation via enhancing AMPK

Chemistry, Nanoscience, Medicine, Neurology, Life Sciences, Biochemistry, Immunology,
neuroinflammation   AMPK   TLR-4   NRF2   IL-6   doxycycline  

Protective Effect of Doxycycline-Loaded Calcium Phosphate Nanoparticles on LPS-Induced Neuroinflammation in Mice In the field of neuroscience research, neuroinflammation is an important pathological feature of many neurological diseases. Neuroinflammation is a complex response of the central nervous system (CNS) to various damaging triggers (such a...

Alleviating CB2-dependent ER stress and mitochondrial dysfunction improves chronic cerebral hypoperfusion-induced cognitive impairment

Medicine, Geriatrics, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
chronic cerebral hypoperfusion   cognitive impairment   endoplasmic reticulum stress   endocannabinoid system   fatty acid amide hydrolase   mitochondria  

Research Overview and Background With the acceleration of global aging, the incidence of ischemic cerebrovascular diseases is also rising significantly. Elderly people over 65 are particularly susceptible to cognitive decline caused by cerebral ischemia, making Chronic Cerebral Hypoperfusion (CCH) a major cause of cognitive impairment and Vascular ...

Lipid Droplet Accumulation Mediates Macrophage Survival and Treg Recruitment via the CCL20/CCR6 Axis in Human Hepatocellular Carcinoma

Medicine, Rheumatology and Immunology, Hepatobiliary System, Basic Medical Sciences, Oncology, Life Sciences, Biochemistry, Immunology,
lipid droplets   macrophage survival   CCL20   Treg   hepatocellular carcinoma  

Lipid Droplet Accumulation Mediates Macrophage Survival and Treg Recruitment in Human Hepatocellular Carcinoma via the CCL20/CCR6 Axis Background Macrophages are a major component of the tumor microenvironment (TME) and regulate the entire tumor process. In the TME, macrophages exhibit dynamic heterogeneity and plasticity, which affects their role ...