Valerenic acid attenuates pathological myocardial hypertrophy by promoting the utilization of multiple substrates in the mitochondrial energy metabolism

Academic Background Pathological Myocardial Hypertrophy (PMH) is an adaptive response of the heart under various pathological stimuli, but its long-term development ultimately leads to Heart Failure (HF). Although some understanding of the pathogenesis of PMH has been established, its mortality rate remains high, and there is an urgent need for new...

Collecting Duct NCOR1 Controls Blood Pressure by Regulating Mineralocorticoid Receptor

Collecting Duct NCOR1 Regulates Blood Pressure by Controlling Mineralocorticoid Receptor Academic Background Hypertension is one of the major risk factors for cardiovascular and cerebrovascular diseases globally, with complex and not fully elucidated mechanisms. The kidney plays a critical role in blood pressure regulation, particularly in the proc...

Metformin Blocks BIK1-Mediated CPK28 Phosphorylation and Enhances Plant Immunity

Metformin Enhances Plant Immunity by Blocking BIK1-Mediated CPK28 Phosphorylation Academic Background In the context of the increasingly severe global food security issues, controlling crop diseases has become a major challenge in agricultural production. Although traditional chemical pesticides can effectively control diseases, the environmental p...

Metal-Free Production of Natural Blue Colorants through Anthocyanin-Protein Interactions

Metal-Free Production of Natural Blue Colorants: Novel Insights from Anthocyanin-Protein Interactions Academic Background With increasing consumer awareness of health and natural food ingredients, the demand for natural colorants has been on the rise. However, natural blue colorants are scarce, and their production poses significant challenges. Cur...

Identification of a Transcription Factor Aomsn2 of the HOG1 Signaling Pathway Contributes to Fungal Growth, Development and Pathogenicity in Arthrobotrys oligospora

The Role of Transcription Factor AoMsn2 in the Hog1 Signaling Pathway in Fungal Growth, Development, and Pathogenicity Background Plant-parasitic nematodes cause significant annual losses to agriculture, while nematode-trapping fungi (NT fungi), due to their ability to capture nematodes by forming specialized trapping structures, have gradually bec...

Unlocking Melanoma Suppression: Insights from Plasma-Induced Potent miRNAs through PI3K-AKT-ZEB1 Axis

Study on Melanoma Suppression by Non-Thermal Atmospheric Pressure Plasma via the PI3K-AKT-ZEB1 Axis Academic Background Melanoma is the most aggressive and deadly form of skin cancer, particularly in its advanced stages, making treatment extremely challenging. Although recent advancements in targeted therapy and immunotherapy have improved patient ...