Spatial Modeling Algorithms for Reactions and Transport in Biological Cells

Life Sciences, Cell Biology, Biochemistry, Bioengineering, Biophysics,
spatial modeling   reaction-transport   cell signaling networks   subcellular structures   finite element analysis   computational biology   membrane reactions  

Research on Spatial Modeling Algorithms for Cellular Signaling Reactions and Transport Background Biological cells achieve their functions through complex biochemical reaction networks. These networks exhibit significant spatiotemporal dynamics, with pronounced spatial compartmentalization across different regions and subcellular structures. Howeve...

A Deep Learning Approach for Rational Ligand Generation with Toxicity Control

Chemistry, Medicinal Chemistry, Information Science, Artificial Intelligence, Life Sciences, Biochemistry,
deep learning   ligand generation   toxicity control   drug design   computational model   block-based generation   molecular optimization  

Latest Research on Deep Learning Applied to Target Protein Ligand Generation: Proposal and Validation of the DeepBlock Framework Background and Research Problem In the drug discovery process, finding ligand molecules that bind to specific proteins has always been a core objective. However, current virtual screening methods are often limited by the ...

Glepaglutide-Loaded Foam for Inducing Mucosal Healing in Inflammatory Bowel Disease Treatment

Chemistry, Medicinal Chemistry, Medicine, Medical Laboratory Science, Gastroenterology, Pharmacy, Life Sciences, Biochemistry, Immunology,
Mucosal Healing   Inflammatory Bowel Disease   Glepaglutide   Local Delivery   Anti-inflammatory Properties  

A Novel Rectal Foam Formulation for the Treatment of Inflammatory Bowel Disease In recent years, the incidence of inflammatory bowel disease (IBD), characterized by mucosal damage, chronic inflammation, and recurrent episodes, has been steadily rising, yet ideal therapeutic solutions remain elusive. Researchers have identified a 33-amino acid pepti...

Kidney Fibrosis in In Vitro and In Vivo Models: Path Toward Physiologically Relevant Humanized Models

Medicine, Basic Medical Sciences, Urology, Nephrology, Life Sciences, Biochemistry, Bioengineering, Immunology,
Kidney fibrosis   Chronic kidney disease   3D humanized models   Disease modeling   Drug development  

Mechanisms and Research Models of Kidney Fibrosis: Progress Toward Physiologically Relevant Humanized Models Research Background and Problem Statement Chronic Kidney Disease (CKD) is a major global public health issue, estimated to affect more than 10% of the population and is one of the leading causes of mortality. Kidney fibrosis, as a key pathol...

Macrophage Membrane-Camouflaged Nanozymes for Combating Oxidative Stress-Microvascular Perfusion Negative Feedback in Ischemia-Reperfusion Induced Acute Kidney Injury

Chemistry, Nanoscience, Medicine, Nephrology, Life Sciences, Biochemistry, Bioengineering, Immunology,
acute kidney injury   macrophage membrane   nanozymes   oxidative stress   microvascular perfusion   renal ischemia-reperfusion   anti-inflammatory therapy  

Innovative Research Report on Intravenous Macrophage Membrane-Camouflaged Nanozymes for Acute Kidney Injury Targeted Therapy Background Introduction Acute kidney injury (AKI) is a severe clinical syndrome characterized by a rapid decline in renal function and is closely associated with high morbidity and mortality. Statistics show that the incidenc...

Facile Fabrication of Injectable Multifunctional Hydrogels Based on Gallium-Polyphenol Networks with Superior Antibacterial Activity for Promoting Infected Wound Healing

Chemistry, Nanoscience, Inorganic Chemistry, Polymer Chemistry, Medicine, Infectious Diseases, Rheumatology and Immunology, Pharmacy, Life Sciences, Biochemistry, Bioengineering, Immunology,
Infected wounds   Hydrogels   Polyphenols   Gallium ions   Antibacterial activity   Antibiotic-resistant pathogens   Wound healing  

A Novel Study on Multifunctional Hydrogels for Promoting Infected Wound Healing In the current clinical setting, infected wounds, especially those caused by antibiotic-resistant pathogens, have become a major challenge. These chronic or hard-to-heal wounds often suffer from delayed healing processes due to excessive inflammation, bacterial biofilm ...