Novel Endocytosis Inhibitors Block Entry of HIV-1 Tat into Neural Cells

Chemistry, Medicinal Chemistry, Medicine, Infectious Diseases, Neurology, Life Sciences, Biochemistry, Immunology,
HIV-1 Tat   endocytosis inhibitors   oxidative stress   DNA damage   neural cells  

Novel Endocytosis Inhibitors Block HIV-1 Tat Protein Entry into Neural Cells Academic Background HIV-1 (human immunodeficiency virus type 1) infection not only leads to immune system exhaustion but is also closely associated with HIV-associated neurocognitive disorders (HAND). Although combined antiretroviral therapy (cART) has significantly improv...

p300 maintains primordial follicle activation by repressing VEGFA transcription

Medicine, Obstetrics and Gynecology, Life Sciences, Cell Biology, Biochemistry, Immunology,
p300   primordial follicle activation   VEGFA   ovarian diseases   premature ovarian insufficiency  

Mechanism Study of p300 Maintaining Primordial Follicle Activation by Inhibiting VEGFA Transcription Academic Background In the female reproductive system, primordial follicles (PFs) are the earliest formed follicles in the ovary, remaining dormant and awaiting activation to enter the growth phase. The activation of primordial follicles is a key fa...

Gut-Kidney Interaction Reinforces Dapagliflozin-Mediated Alleviation in Diabetic Nephropathy

Medicine, Endocrinology, Nephrology, Life Sciences, Biochemistry, Immunology,
Dapagliflozin   Diabetic Nephropathy   Gut Microbiota   Gut-Kidney Axis   Metabolites  

Mechanism Study of Dapagliflozin Improving Diabetic Nephropathy via the Gut-Kidney Axis Academic Background Diabetic nephropathy (DN) is one of the most common microvascular complications of diabetes, with approximately 40% of individuals with type 1 or type 2 diabetes developing DN in the advanced stages of the disease. Although clinical managemen...

Proteomic Analysis Reveals Distinct Cerebrospinal Fluid Signatures Across Genetic Frontotemporal Dementia Subtypes

Medicine, Medical Laboratory Science, Neurology, Life Sciences, Biochemistry, Genetics,
proteomics   frontotemporal dementia   cerebrospinal fluid   genetic mutations   neurodegenerative diseases  

Academic Background Frontotemporal Dementia (FTD) is a group of progressive neurodegenerative diseases characterized primarily by behavioral changes, language impairment, or motor dysfunction. Although the incidence of FTD is lower than that of Alzheimer’s Disease (AD), it remains one of the leading causes of early-onset dementia. The molecular bas...

Early Detection of Pancreatic Cancer by a High-Throughput Protease-Activated Nanosensor Assay

Chemistry, Nanoscience, Medicine, Oncology, Life Sciences, Biochemistry, Bioengineering,
pancreatic cancer   early detection   nanosensor   protease   liquid biopsy  

New Method for Early Detection of Pancreatic Cancer—A Protease-Activated Nanosensor Assay Background Pancreatic Ductal Adenocarcinoma (PDAC) is one of the leading causes of cancer-related deaths worldwide. Due to its nonspecific early symptoms, most patients are diagnosed at advanced stages, resulting in limited treatment options and poor prognosis...

Antisense Oligonucleotide–Mediated MSH3 Suppression Reduces Somatic CAG Repeat Expansion in Huntington’s Disease iPSC–Derived Striatal Neurons

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
Huntington's disease   CAG repeat expansion   antisense oligonucleotide   iPSC-derived neurons   MSH3 protein  

Therapeutic Potential of ASO-Mediated MSH3 Suppression in Huntington’s Disease Academic Background Huntington’s disease (HD) is a neurodegenerative disorder caused by abnormal expansion of the CAG repeat sequence in the huntingtin gene (HTT). This expanded CAG repeat continues to expand somatically over time, driving the onset and progression of th...