Schlafen 11 Triggers Innate Immune Responses

Medicine, Rheumatology and Immunology, Life Sciences, Immunology,
Innate immunity   Single-stranded DNA   Schlafen 11   Cytokine expression   Pathogen infection   Immune system  

New Findings on the Detection of Single-Stranded DNA by the Human Immune System: The Role of Schlafen 11 in Innate Immune Response Research Background In the innate immune system, pattern recognition receptors (PRRs) play a crucial role. They initiate an immune response by recognizing pathogen-associated molecular patterns (PAMPs) and damage-associ...

The Tumor-Intrinsic Role of the m6A Reader YTHDF2 in Regulating Immune Evasion

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Tumor Immune Evasion   Immunotherapy   YTHDF2   m6A   Tumor Microenvironment   Immune Surveillance   Anti-PD-L1 Therapy  

Report: Intrinsic Role of m6A Reader Protein YTHDF2 in Regulating Tumor Immune Evasion Background Introduction In recent years, immunotherapy has become a hotspot in the field of tumor treatment, attracting attention for its ability to break through immune suppression barriers or enhance existing anti-tumor immunity. However, despite some successes...

Intratumoral Antigen Signaling Traps CD8+ T Cells to Confine Exhaustion to the Tumor Site

Medicine, Rheumatology and Immunology, Oncology, Life Sciences, Immunology,
cancer immunology   CD8+ T cells   antigen signaling   clonal expansion   T cell exhaustion  

Tumor Immunology Research: The Exhausted State of CD8+ T Cells in Tumors In recent years, immunotherapy has achieved significant progress in the field of tumor treatment. However, tracking the behavior of lymphocytes following antigen signals remains challenging. This study aims to address this issue by developing Antigen Receptor Signaling Reporte...

Circulating KLRG1+ Long-Lived Effector Memory T Cells Retain the Flexibility to Become Tissue Resident

Medicine, Rheumatology and Immunology, Life Sciences, Cell Biology, Immunology, Microbiology,
Memory T cells   Long-lived effector cells   KLRG1+   Pathogen   Tissue residency   Antigen presentation   Transcriptional signature  

Tissue-Resident Capacity of Long-Term Surviving KLRG1+ Effector Memory T Cells Background Memory CD8 T cells play a crucial role in the body’s defense against pathogen reinfection. Memory T cells are a heterogeneous group of cells present in various tissues throughout the body, providing essential surveillance and rapid response functions. Memory T...

Functional Correlation between Myeloid Cells and Membrane Abundance

Medicine, Rheumatology and Immunology, Life Sciences, Cell Biology, Immunology, Biophysics,
myeloid cells   membrane abundance   phagocytosis   G protein β4 subunit   cell migration   biophysical regulation  

In the past few decades, with the rapid development of science and technology, human understanding of the immune system has continuously deepened. Among all immune cells, professional phagocytes (such as neutrophils and macrophages) play a crucial role in clearing apoptotic cells, cell debris, and invading pathogens. These cells uptake and engulf f...

Overexpression of MALAT1 Drives Metastasis Through Inflammatory Reprogramming of the Tumor Microenvironment

Medicine, Oncology, Life Sciences, Immunology,
MALAT1   lung adenocarcinoma   metastasis   inflammatory reprogramming   tumor microenvironment  

Cancer Immunology Research: Overexpression of MALAT1 Drives Lung Adenocarcinoma Metastasis Through Inflammatory Reprogramming Background Introduction MALAT1 (Metastasis-associated Lung Adenocarcinoma Transcript 1) is a long noncoding RNA (lncRNA) closely linked to tumor progression and metastasis in several cancers, including lung adenocarcinoma (L...