Salivary Testosterone Levels and Pain Perception Exhibit Sex-Specific Association in Healthy Adults but Not in Patients with Migraine

Medicine, Rheumatology and Immunology, Psychiatry, Endocrinology, Neurology, Life Sciences, Immunology,
salivary testosterone   pain perception   migraine   sex-specific   quantitative sensory testing  

The Level of Salivary Testosterone and Pain Perception Show Sex-Specific Associations in Healthy Adults, But Not in Migraine Patients Introduction Understanding the complexity of pain and the role gender plays in pain perception is of significant importance in medical research. Pain is an unpleasant sensory and emotional experience associated with ...

Single-Subject Cortical Morphological Brain Networks: Phenotypic Associations and Neurobiological Substrates

Medicine, Basic Medical Sciences, Neurology, Medical Imaging, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics, Biophysics,
morphological brain network   structural magnetic resonance imaging   cortical thickness   sex   neurotransmitter  

This paper is a study on the phenotypic associations and neurobiological bases of single-subject morphological brain networks. Combining multimodal and multiscale data, this study reveals the differences in morphological brain networks between genders, their potential as individual-specific markers, and their relationships with gene expression, lay...

Histone 3 Lysine 9 Acetylation-Specific Reprogramming Regulates Esophageal Squamous Cell Carcinoma Progression and Metastasis

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Histone H3   Lysine 9 Acetylation   Esophageal Squamous Cell Carcinoma   Progression   Metastasis   Epigenetic Reprogramming  

The Mechanism of Action of Specific Reprogramming of Histone H3 Lysine 9 Acetylation (H3K9ac) in the Progression and Metastasis of Esophageal Squamous Cell Carcinoma (ESCC) Background Esophageal cancer is one of the most prevalent and invasive malignant tumors globally, causing over 500,000 cancer-related deaths annually, ranking sixth among cancer...

Modification of the Tumor Microenvironment Enhances Immunity with Plasmid Gene Therapy

Medicine, Rheumatology and Immunology, Oncology, Life Sciences, Biochemistry, Immunology,
tumor microenvironment   plasmid gene therapy   immunity   MHC-I   PD-L1   antitumor effect   electroporation  

The research team consisting of Guilan Shi, Jody Synowiec, Julie Singh, and Richard Heller published a paper titled “Modification of the tumor microenvironment enhances immunity with plasmid gene therapy” in Cancer Gene Therapy. The background of the study stems from current challenges in the field of tumor immunotherapy, such as tumor cells evadin...

Schwann cell derived pleiotrophin stimulates fibroblast proliferation and excessive collagen deposition in plexiform neurofibroma

Medicine, Medical Laboratory Science, Oral Sciences, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Schwann cells   pleiotrophin   fibroblasts   plexiform neurofibroma   collagen deposition   signaling pathway  

This study explores the interactions between Schwann cells and fibroblasts in neurofibromatosis type 1 (NF1) related plexiform neurofibroma (PNF). The background of the research is based on the high incidence of NF1, which affects about 1 in 3000 newborns worldwide and is associated with a series of unique clinical manifestations. PNF is a common p...

GRIN2A mutation is a novel indicator of stratifying beneficiaries of immune checkpoint inhibitors in multiple cancers

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Oncology, Life Sciences, Biochemistry, Immunology,
GRIN2A mutation   cancer immunotherapy   immune checkpoint inhibitors   tumor mutational burden   tumor-infiltrating immune cells  

GRIN2A Mutations as a Novel Indicator for Stratifying Beneficiaries of Immune Checkpoint Inhibitors in Various Cancers Background Immune checkpoint inhibitors (ICIs) therapy, which modulates the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death (ligand) 1 (PD-(L)1) pathways, has made revolutionary progress in treating v...