YAP Inhibits the TEAD-NF-κB Complex and Suppresses the Growth of Clear Cell Renal Cell Carcinoma Research Background Conventionally, the Hippo signaling pathway inhibits YAP-TEAD transcriptional complexes by keeping the transcriptional coactivator YAP phosphorylated and retained in the cytoplasm, thereby impeding tumor growth. However, researchers ...
In the context of today’s rapid advancement in science and technology, immunotherapy with natural killer (NK) cells has attracted widespread attention in the scientific community for their potential advantages in combating tumors and viral infections. Especially, the discovery of memory-like NK cells has brought new hope for NK cells as an anticanc...
Research on Network Construction and Application of Novel Drug Repositioning Strategies Background During the COVID-19 pandemic, researchers and pharmaceutical companies have been dedicated to developing treatments and vaccines. Drug repositioning, due to its shortcut, is considered a rapid and effective response strategy. Drug repositioning attemp...
Research Report on Immunotherapy Efficacy Prediction for Non-Small Cell Lung Cancer: A Study of Multi-View Adaptive Weighted Graph Convolutional Networks Background Introduction Lung cancer is a highly prevalent and poorly prognostic malignant tumor with a persistently high mortality rate. Among all lung cancer patients, Non-Small Cell Lung Cancer ...
Thalamocortical Connectivity Reduction in Rolandic Epilepsy Rolandic Epilepsy (RE), also known as self-limited epilepsy with centrotemporal spikes (SELECTS), is the most common localized developmental epileptic encephalopathy. This type of epilepsy is typically accompanied by transient mild to severe cognitive symptoms, sleep-related rolandic spike...
The Level of Salivary Testosterone and Pain Perception Show Sex-Specific Associations in Healthy Adults, But Not in Migraine Patients Introduction Understanding the complexity of pain and the role gender plays in pain perception is of significant importance in medical research. Pain is an unpleasant sensory and emotional experience associated with ...