Increased IL-6 Levels and the Upregulation of Iron Regulatory Biomarkers Contribute to the Progression of Japanese Encephalitis Virus Infection's Pathogenesis

Medicine, Infectious Diseases, Neurology, Hematology, Life Sciences, Cell Biology, Immunology,
Japanese encephalitis virus infection   hepcidin   transferrin   transferrin receptors   IL-6  

Elevated IL-6 Levels and Upregulation of Iron-Regulatory Biomarkers Promote Japanese Encephalitis Virus Infection In this research paper, the authors explore changes in inflammatory response and iron-regulatory biomarkers during Japanese Encephalitis Virus (JEV) infection. A comprehensive analysis of iron-regulatory biomarkers and inflammatory resp...

Uncovering Sex-Specific Epigenetic Regulatory Mechanism Involving H3K9me2 in Neural Inflammation, Damage, and Recovery in the Internal Carotid Artery Occlusion Mouse Model

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
cerebral ischemia   sex-difference   inflammation   KDM4B/JMJD2B   striatum   epigenetics  

Research Reveals Gender-Specific Epigenetic Regulatory Mechanisms in Neuroinflammation, Injury, and Recovery Background Ischemic stroke is one of the leading causes of death and disability worldwide. Due to limited understanding of its linked disease mechanisms, current treatments for alleviating acute ischemic brain injury are very limited. Recent...

Inhibition of p70 Ribosomal S6 Kinase (S6K1) Reduces Cortical Blood Flow in a Rat Model of Autism-Tuberous Sclerosis

Medicine, Neurology, Life Sciences, Cell Biology, Immunology,
p70 ribosomal S6 kinase   cerebral blood flow   tuberous sclerosis complex   autism spectrum disorders   pf-4708671  

Inhibition of p70 ribosomal S6 kinase (S6K1) Reduces Cerebral Cortical Blood Flow in Autism-Tuberous Sclerosis Rats: Research Report Background Tuberous Sclerosis Complex (TSC) is a genetic disorder caused by mutations in the TSC1 or TSC2 genes, primarily characterized by multiple benign tumors, including symptoms such as epilepsy, autism spectrum ...

Long-term accumulation of T cytotoxic 1, T cytotoxic 17, and T cytotoxic 17/1 cells in the brain contributes to microglia-mediated chronic neuroinflammation after ischemic stroke

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
ischemic stroke   brain   cd8+ t cells   neuroinflammation   immunity  

Long-term Effects of CD8+ T Cell Subsets in Neuroinflammation After Ischemic Stroke Background Ischemic stroke is a leading cause of death and disability. After stroke, neuroinflammation is rapidly induced, activating various cells such as mast cells, astrocytes, microglia, and vascular endothelial cells. These reactive cells then express various i...

Lycium Barbarum Polysaccharides Improves Cognitive Functions in ICV-STZ-Induced Alzheimer’s Disease Mice Model by Improving the Synaptic Structural Plasticity and Regulating IRS1/PI3K/AKT Signaling Pathway

Medicine, Medical Laboratory Science, Geriatrics, Neurology, Life Sciences, Biochemistry, Bioengineering, Immunology,
Alzheimer’s disease   ICV-STZ   insulin resistance   neurodegeneration   synapse  

Study on the Improvement of Cognitive Function in ICV-STZ-Induced Alzheimer’s Disease Mouse Model by Lycium Barbarum Polysaccharides Research Background Alzheimer’s disease (AD) is the most common neurodegenerative disease of the central nervous system, characterized by progressive cognitive impairment, memory loss, personality changes, and emotion...

Activation of Central Nervous System Immunity: A Study on Resiquimod Mechanism

Medicine, Rheumatology and Immunology, Neurology, Life Sciences, Immunology,
Resiquimod   TLR7   Central Nervous System   Immune Response   Neurocytes   Inflammatory Chemokines   NF-κB  

TLR7 Induces CCL2 Expression in Neurons via NF-κB Research Background Toll-like receptors (TLRs) are one of the important mechanisms for recognizing specific molecular structures of microbes. In humans, ten TLRs (TLR1-10) are known, among which TLR3 and TLR7 are located on the endosomal membrane and play important roles in sensing virus-derived nuc...