Genome, HLA and Polygenic Risk Score Analyses for Prevalent and Persistent Cervical Human Papillomavirus (HPV) Infections

Medicine, Infectious Diseases, Obstetrics and Gynecology, Oncology, Life Sciences, Biochemistry, Immunology, Genetics,
Genome   HLA   Polygenic Risk Score   Cervical HPV   Persistent Infection  

Genome-wide and Polygenic Risk Score Analysis of High-Risk Human Papillomavirus (hrHPV) Infection in the Cervix Background Cervical high-risk human papillomavirus (hrHPV) infection is the second largest carcinogenic infection globally, accounting for approximately 31.4% of all infection-related cancers (about 690,000 cases out of 2.2 million cancer...

Uncertainties Experienced by Parents of Children Diagnosed with Severe Combined Immunodeficiency Through Newborn Screening

Medicine, Pediatrics, Rheumatology and Immunology, Life Sciences, Immunology, Genetics,
Severe Combined Immunodeficiency   Newborn Screening   Uncertainty   Parental Experience   Healthcare   Emotional Support  

Instant Inclusion: In-depth Analysis of Uncertainties Experienced by Parents of Newborns with Severe Combined Immunodeficiency Research Background Severe Combined Immunodeficiency (SCID) is a rare and potentially fatal genetic disorder. Without timely diagnosis and treatment, patients face life-threatening conditions. In recent years, early identif...

MDGA2 Constrains Glutamatergic Inputs Selectively onto CA1 Pyramidal Neurons to Optimize Neural Circuits for Plasticity, Memory, and Social Behavior

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
MDGA2   CA1 Pyramidal Neurons   Glutamatergic Inputs   Synaptic Plasticity   Memory   Social Behaviors   Autism  

In the field of neuroscience, synaptic organization and plasticity are crucial for cognitive functions such as memory and social behavior. As rare synaptic inhibitory factors, members of the family known as MAM domain-containing glycosylphosphatidylinositol anchor proteins (MDGA) play an important regulatory role in synapse formation by inhibiting ...

Mapping the Behavioral Signatures of Shank3B Mice in Both Sexes

Medicine, Psychiatry, Neurology, Neurosurgery, Life Sciences, Immunology,
Autism   Shank3B   Spontaneous Behavior   3D Animal Motion-Capture System   Computational Ethology   Sex Differences  

Behavioral Characterization of Shank3B Mice Across Both Sexes Research Background Autism Spectrum Disorder (ASD) is a group of complex mental disorders characterized by abnormalities in social interaction and repetitive behaviors. The Shank3B mutant ASD mouse model is widely used in research; however, the behavioral phenotype of this model has not ...

Low-Frequency Stimulation at the Subiculum Prevents Extensive Secondary Epileptogenesis in Temporal Lobe Epilepsy

Medicine, Basic Medical Sciences, Neurology, Neurosurgery, Life Sciences, Immunology,
secondary epileptogenesis   low-frequency stimulation   subiculum   temporal lobe epilepsy   epilepsy   pharmacoresistance   epileptic surgery  

In the field of neuroscience, epilepsy has always been a disease of great concern, with significant challenges remaining in clinical research and treatment. Among these, the issue of secondary epileptogenesis has had a profound impact on academia and clinical treatment. Secondary epileptogenesis refers to the continuous spread of epileptic activity...

The Chemokine CCL2 Promotes Excitatory Synaptic Transmission in Hippocampal Neurons via GluA1 Subunit Trafficking

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology, Biophysics,
Cytokines   CCL2/MCP-1   Synaptic Transmission   AMPA Receptors   GluA1  

In the latest research paper “Chemokine CCL2 Promotes Excitatory Synaptic Transmission in Hippocampal Neurons via GluA1 Subunit Trafficking” published in “Neurosci. Bull.”, researchers from multiple institutions, including the Shanghai Institute of Neuroscience, Chinese Academy of Sciences, and the School of Life Sciences, Peking University, have d...