In the field of functional genomics, researchers have long been dedicated to predicting causal regulatory relationships from observational data. However, despite modern technologies enabling the measurement of diverse molecular modalities, inferring causal regulatory relationships from observational data remains challenging. In particular, the iden...
Background Introduction Single-cell RNA sequencing (scRNA-seq) technology has been widely applied in biomedical research in recent years, as it can reveal the heterogeneity of gene expression at the single-cell level, providing an important tool for understanding cell types, cell states, and disease mechanisms. However, scRNA-seq data is characteri...
Academic Background Introduction The spliceosome is a highly dynamic macromolecular complex responsible for the precise excision of introns from pre-mRNA. Although recent advances in cryo-electron microscopy (cryo-EM) have provided a comprehensive structural understanding of the stepwise assembly, catalytic splicing, and final disassembly of the sp...
Academic Background The completion of the Human Genome Project has greatly advanced our understanding of complex biological processes at the genome-wide level. However, only about 1% of the genome encodes proteins, with the majority consisting of non-coding regions that produce abundant non-coding RNAs (ncRNAs), such as long non-coding RNAs (lncRNA...
Breast cancer is one of the most common malignant tumors among women worldwide, with a complex pathogenesis involving multiple gene mutations and signaling pathway abnormalities. Homologous Recombination Deficiency (HRD) is a significant molecular characteristic in breast cancer, closely related to patients’ sensitivity to PARP inhibitor (PARPi) th...
Academic Background Aortic aneurysm (AA) is a condition characterized by abnormal dilation of the aorta, commonly occurring in the abdominal and thoracic aorta. Aortic aneurysms are more prevalent in individuals over the age of 65, and if not diagnosed and treated promptly, they can lead to fatal ruptures. Although age, smoking, hypertension, and m...