Mapping the Cellular Etiology of Schizophrenia and Complex Brain Phenotypes

Medicine, Psychiatry, Life Sciences, Cell Biology, Genetics,
schizophrenia   brain phenotypes   cell types   genome-wide association studies   transcriptomics  

Cell-Type Classification of Psychiatric Disorders: New Study Reveals Cellular Basis of Schizophrenia and Other Complex Brain Disorders Academic Background Psychiatric disorders, such as schizophrenia, depression, and bipolar disorder, are significant public health issues worldwide. These disorders are typically caused by a combination of multiple g...

Aberrant Splicing in Huntington’s Disease Accompanies Disrupted TDP-43 Activity and Altered m6A RNA Modification

Medicine, Neurology, Life Sciences, Cell Biology, Genetics,
Huntington’s Disease   TDP-43   m6A RNA modification   aberrant splicing   neurodegenerative disorder  

Aberrant Splicing in Huntington’s Disease Accompanies Disrupted TDP-43 Activity and Altered m6A RNA Modification Academic Background Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms. The disease is caused by a CAG repeat expansion in the HTT gene, leading to ab...

Proteomic Analysis Reveals Distinct Cerebrospinal Fluid Signatures Across Genetic Frontotemporal Dementia Subtypes

Medicine, Medical Laboratory Science, Neurology, Life Sciences, Biochemistry, Genetics,
proteomics   frontotemporal dementia   cerebrospinal fluid   genetic mutations   neurodegenerative diseases  

Academic Background Frontotemporal Dementia (FTD) is a group of progressive neurodegenerative diseases characterized primarily by behavioral changes, language impairment, or motor dysfunction. Although the incidence of FTD is lower than that of Alzheimer’s Disease (AD), it remains one of the leading causes of early-onset dementia. The molecular bas...

Antisense Oligonucleotide–Mediated MSH3 Suppression Reduces Somatic CAG Repeat Expansion in Huntington’s Disease iPSC–Derived Striatal Neurons

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
Huntington's disease   CAG repeat expansion   antisense oligonucleotide   iPSC-derived neurons   MSH3 protein  

Therapeutic Potential of ASO-Mediated MSH3 Suppression in Huntington’s Disease Academic Background Huntington’s disease (HD) is a neurodegenerative disorder caused by abnormal expansion of the CAG repeat sequence in the huntingtin gene (HTT). This expanded CAG repeat continues to expand somatically over time, driving the onset and progression of th...

In Vivo Expansion of Gene-Targeted Hepatocytes through Transient Inhibition of an Essential Gene

Medicine, Hepatobiliary System, Life Sciences, Bioengineering, Genetics,
gene therapy   hepatocytes   in vivo expansion   essential gene   genome editing  

Breakthrough in Gene Therapy: Repair Drive Technology Enables In Vivo Expansion of Hepatocytes Academic Background Gene therapy has become a hot topic in medical research in recent years, especially for liver diseases. Due to the central role of the liver in metabolism, it has become a critical target for research. Although existing gene-editing te...

Ciliopathies: Undocking of an Extensive Ciliary Network Induces Proteostasis and Cell Fate Switching Resulting in Severe Primary Ciliary Dyskinesia

Medicine, Respiratory System, Life Sciences, Cell Biology, Biochemistry, Genetics,
Primary Ciliary Dyskinesia   Ciliary Network   Proteostasis   Cell Fate Switching   Gene Therapy  

Research on Ciliary Diseases: The Role of CCDC39/CCDC40 Heterodimer in Primary Ciliary Dyskinesia Academic Background Primary Ciliary Dyskinesia (PCD) is a rare monogenic disorder characterized by chronic respiratory infections, infertility, and organ laterality defects. Although more than 50 genes associated with PCD have been identified, mutation...