Epigenome-Wide Association Studies Identify Novel DNA Methylation Sites Associated with PTSD: A Meta-Analysis of 23 Military and Civilian Cohorts

Medicine, Psychiatry, Life Sciences, Biochemistry, Genetics,
PTSD   DNA methylation   post-traumatic stress disorder   epigenetics   gene expression   meta-analysis   genome-wide association studies  

Epigenome-wide DNA Methylation Study Highlights PTSD-Associated Sites: A Meta-Analysis Across 23 Military and Civilian Cohorts Background and Research Objectives Post-Traumatic Stress Disorder (PTSD) is a serious psychiatric condition triggered by exposure to traumatic events. It is characterized by intrusive memories, avoidance or emotional numbne...

Patterns of Genomic Instability in Ovarian Cancer Patients

Medicine, Obstetrics and Gynecology, Oncology, Life Sciences, Biochemistry, Genetics,
ovarian cancer   genomic instability   PARP inhibitors   homologous recombination deficiency   clinical trials   BRCA mutations   precision medicine  

Background and Research Question Ovarian cancer, as a fatal gynecological malignancy, has become the focus of recent studies, particularly on expanding the feasibility of targeted therapies. The introduction of poly(ADP-ribose) polymerase (PARP) inhibitors has marked a groundbreaking treatment option for ovarian cancer, especially for patients with...

Revisiting Mutational Resistance to Ampicillin and Cefotaxime in Haemophilus influenzae

Medicine, Infectious Diseases, Life Sciences, Biochemistry, Genetics, Microbiology,
Haemophilus influenzae   ampicillin resistance   cefotaxime resistance   BLNAR   MIC   genome-wide association study   phylogenomics  

Revisiting Mutational Resistance to Ampicillin and Cefotaxime in Haemophilus influenzae Background and Motivation for the Study Haemophilus influenzae is an opportunistic bacterial pathogen that can cause severe respiratory tract infections and invasive infections such as septicemia and meningitis, particularly in infants, the elderly, and immunoco...

Using Multiplexed Functional Data to Reduce Variant Classification Inequities in Underrepresented Populations

Medicine, Life Sciences, Genetics,
multiplexed functional data   variant classification   inequity   underrepresented populations   genome medicine   variant effects   clinical significance  

Title: “Using Multiplexed Functional Data to Reduce Variant Classification Inequities in Underrepresented Populations” Authors and Publishing Information: The paper, authored by Moez Dawood et al., is published in the journal Genome Medicine (2024, Volume 16, Issue 143). The authors represent multiple institutions such as Baylor College of Medicine...

Integrated Analyses of Multi-Omic Data Reveal Metabolic Vulnerability as a Novel Therapeutic Target in Lung Cancer Brain Metastases

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
Lung cancer brain metastases   Metabolic vulnerability   Tumor immune microenvironment   Multi-omic analysis   Mitochondrial metabolism  

Report on the Multi-Omics Study of Lung Cancer Brain Metastases (LC-BMs) Academic Background Lung cancer is one of the most prevalent and deadly cancers worldwide. Lung cancer brain metastases (LC-BMs) are a common complication in patients with lung cancer and are associated with poor prognosis. Despite advances in lung cancer therapies, the standa...

Genome-aware annotation of CRISPR guides validates targets in variant cell lines and enhances discovery in screens

Medicine, Oncology, Life Sciences, Cell Biology, Bioengineering, Genetics,
CRISPR   genome annotation   bioinformatics   computational biology   software tool  

Genomic Medicine and Re-annotation of CRISPR Guides: Application and Validation of the EXORCISE Algorithm Academic Background The advent of CRISPR-Cas9 technology has revolutionized genetic screening, particularly in studying gene essentiality and chemo-genetic interactions. By designing guide RNAs (gRNAs) that target specific genes, the CRISPR-Cas...