The Role of lncRNA-Mediated ceRNA Network in Penile Squamous Cell Carcinoma

Medicine, Urology, Oncology, Life Sciences, Immunology, Genetics,
long non-coding RNA   competing endogenous RNA network   penile squamous cell carcinoma   tumor microenvironment   immunosuppression  

The Role of lncRNA-Mediated ceRNA Network in Penile Squamous Cell Carcinoma Academic Background Penile Squamous Cell Carcinoma (PSCC) is a relatively rare but life-threatening malignancy that poses a significant health risk to men, particularly in developing countries. Despite advancements in medical diagnosis and treatment, the overall survival ra...

Combined Single Cell and Spatial Transcriptome Analysis Reveals Cellular Heterogeneity of Hedgehog Pathway in Gastric Cancer

Medicine, Gastroenterology, Oncology, Life Sciences, Cell Biology, Immunology, Genetics,
Gastric Cancer   Hedgehog Pathway   Single-Cell Sequencing   Spatial Transcriptomics   Tumor Microenvironment   CCND1   Fibroblasts  

Combined Single-Cell and Spatial Transcriptome Analysis Reveals Cellular Heterogeneity of the Hedgehog Pathway in Gastric Cancer Academic Background Gastric cancer (GC) is one of the most common and deadly malignancies worldwide, with high incidence and mortality rates. Despite advancements in chemotherapy, radiotherapy, and targeted therapy, the t...

A Potential Coagulation-Related Diagnostic Model Associated with Immune Infiltration for Acute Myocardial Infarction

Medicine, Cardiovascular System, Life Sciences, Immunology, Genetics,
Acute Myocardial Infarction   Coagulation-Related Genes   Immune Infiltration   Diagnostic Model   Random Forest Algorithm  

Potential Coagulation-Related Diagnostic Model Associated with Immune Infiltration for Acute Myocardial Infarction Academic Background Acute Myocardial Infarction (AMI) is one of the leading causes of death worldwide. Despite significant advancements in diagnosis, treatment, and prognosis in recent years, the incidence and mortality rates of AMI re...

Regulatory T Cells-Related Gene in Primary Sclerosing Cholangitis: Evidence from Mendelian Randomization and Transcriptome Data

Medicine, Hepatobiliary System, Medical Laboratory Science, Gastroenterology, Life Sciences, Immunology, Genetics,
Primary Sclerosing Cholangitis   Regulatory T Cells   Mendelian Randomization   Transcriptome Data   Machine Learning   Immune Cell Infiltration   Molecular Pathways  

Regulatory T Cells-Related Gene in Primary Sclerosing Cholangitis: Evidence from Mendelian Randomization and Transcriptome Data Authors: Jianlan Hu1, Youxing Wu1, Danxia Zhang1, Xiaoyang Wang1, Yaohui Sheng1, Hui Liao1, Yangpeng Ou2✉, Zhen Chen3, Baolian Shu1✉, and Ruohu Gui1✉ Journal: Genes & Immunity (2024) 25:492–513 DOI: https://doi.org/10.1038...

Nucleosome Fibre Topology Guides Transcription Factor Binding to Enhancers

Life Sciences, Cell Biology, Biochemistry, Genetics, Biophysics,
nucleosome   transcription factor   enhancer   chromatin   cellular reprogramming  

Nucleosome Fibre Topology Guides Transcription Factor Binding to Enhancers Academic Background The establishment of cellular identity relies on the concerted action of multiple transcription factors (TFs) bound to enhancers of cell-type-specific genes. Although TFs recognize specific DNA motifs within accessible chromatin, this information alone is...

Engineered Extrachromosomal Oncogene Amplifications Promote Tumorigenesis

Medicine, Oncology, Life Sciences, Cell Biology, Genetics,
extrachromosomal DNA   oncogene amplification   tumorigenesis   genetic engineering   mouse models  

Academic Background and Problem Statement In cancer research, gene amplification is a common form of mutation, particularly in the activation of oncogenes. However, despite the widely recognized importance of gene amplification in cancer, precisely modeling these amplifications in primary cells and model organisms remains a challenge. Specifically,...