Leveraging a Phased Pangenome for Haplotype Design of Hybrid Potato

Life Sciences, Genetics, Botany,
potato   pangenome   haplotype design   hybrid breeding   structural variants   deleterious mutations   genomic diversity  

Leveraging a Phased Pangenome for Haplotype Design of Hybrid Potato Academic Background Potato (Solanum tuberosum L.) is one of the most important tuber crops globally, providing food for over 1.3 billion people annually across more than 120 countries. However, the tetraploid genome and clonal propagation of potatoes result in slow breeding progres...

Rapid and Scalable Personalized ASO Screening in Patient-Derived Organoids

Medicine, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
personalized therapeutics   antisense oligonucleotides   rare diseases   organoid models   gene therapy   Duchenne muscular dystrophy   stem cells  

Establishment of a Personalized Antisense Oligonucleotide (ASO) Screening Platform Based on Patient-Derived Organoids Academic Background In recent years, with the rapid development of genome sequencing technologies, an increasing number of rare genetic diseases have been found to be associated with specific gene mutations. Antisense oligonucleotid...

Multisite DNA Methylation Alterations of Peripheral Blood Mononuclear Cells Serve as Novel Biomarkers for the Diagnosis of AIS/Stage I Lung Adenocarcinoma: A Multicenter Cohort Study

Medicine, Respiratory System, Oncology, Life Sciences, Biochemistry, Genetics,
DNA methylation   early detection   lung adenocarcinoma   peripheral blood mononuclear cells   biomarkers   multicenter study   epigenetics  

Novel Early Diagnosis Method for Lung Adenocarcinoma Based on DNA Methylation in Peripheral Blood Mononuclear Cells Background Lung adenocarcinoma (LUAD) is one of the leading causes of cancer-related deaths worldwide, accounting for approximately 40% of lung cancer cases. Despite significant advancements in treatment, the prognosis of LUAD remains...

Combination of Biological Aging and Genetic Susceptibility Helps Identifying At-Risk Population of Venous Thromboembolism: A Prospective Cohort Study of 394,041 Participants

Medicine, Geriatrics, Hematology, Cardiovascular System, Life Sciences, Genetics,
biological aging   phenotypic age   polygenic risk score   risk stratification   venous thromboembolism  

Combining Biological Aging and Genetic Susceptibility to Identify High-Risk Populations for Venous Thromboembolism Academic Background Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is the third most fatal cardiovascular disease globally. The incidence of VTE is closely related to age, particularly i...

Polymorphic Single-Nucleotide Variants in miRNA Genes and the Susceptibility to Colorectal Cancer: Combined Evaluation by Pairwise and Network Meta-Analysis, Thakkinstian's Algorithm and FPRP Criterium

Medicine, Oncology, Life Sciences, Biochemistry, Genetics,
colorectal cancer   miRNA   single-nucleotide polymorphism   network meta-analysis   Thakkinstian's algorithm   false positive report probability   susceptibility  

Association Study of Polymorphic Single-Nucleotide Variants in miRNA Genes and Colorectal Cancer Susceptibility Academic Background Colorectal cancer (CRC) is one of the most common malignancies with high incidence and mortality rates worldwide. According to global cancer statistics in 2022, CRC ranks as the third most prevalent cancer, with over 1...

Circulating Extracellular Vesicles as Promising Biomarkers for Precision Diagnostics: A Perspective on Lung Cancer

Medicine, Respiratory System, Oncology, Life Sciences, Biochemistry, Bioengineering, Immunology, Genetics, Biophysics,
extracellular vesicles   lung cancer   liquid biopsy   biosensors   early detection   precision medicine   nanotechnology  

Exosomes as Biomarkers for Precision Diagnosis of Lung Cancer Academic Background Lung cancer is one of the leading causes of cancer-related deaths worldwide, with early diagnosis and precision treatment of non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) remaining significant challenges. Although traditional tissue biopsy is co...