Circulating Extracellular Vesicles as Promising Biomarkers for Precision Diagnostics: A Perspective on Lung Cancer

Medicine, Respiratory System, Oncology, Life Sciences, Biochemistry, Bioengineering, Immunology, Genetics, Biophysics,
extracellular vesicles   lung cancer   liquid biopsy   biosensors   early detection   precision medicine   nanotechnology  

Exosomes as Biomarkers for Precision Diagnosis of Lung Cancer Academic Background Lung cancer is one of the leading causes of cancer-related deaths worldwide, with early diagnosis and precision treatment of non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) remaining significant challenges. Although traditional tissue biopsy is co...

Enhancing Gene Delivery to Breast Cancer with Highly Efficient siRNA Loading and pH-Responsive Small Extracellular Vesicles

Enhancing Gene Delivery to Breast Cancer with Highly Efficient siRNA Loading and pH-Responsive Small Extracellular Vesicles

Chemistry, Medicinal Chemistry, Chemical Engineering, Medicine, Oncology, Life Sciences, Biochemistry, Bioengineering, Genetics,
small extracellular vesicles   gene delivery   pH-responsive   graphene quantum dots   lysosomal escape   breast cancer   siRNA  

Enhancing Gene Delivery to Breast Cancer with Highly Efficient siRNA Loading and pH-Responsive Small Extracellular Vesicles Academic Background In recent years, small extracellular vesicles (sEVs) have become a hot topic in the field of drug delivery due to their natural origin and inherent homing properties. sEVs are lipid nanoparticles secreted b...

Simultaneous Detection of Eight Cancer Types Using a Multiplex Droplet Digital PCR Assay

Medicine, Oncology, Life Sciences, Biochemistry, Genetics,
cancer detection   DNA methylation   droplet digital PCR   multiplexing   biomarkers   early diagnosis   tumor prediction  

Multi-Cancer Detection Using Multiplex Droplet Digital PCR Methylation Assay Background Cancer is one of the leading causes of death worldwide, with nearly 10 million deaths reported in 2020. Although many cancers can be cured when detected and treated early, many patients are still diagnosed at advanced stages, leading to poor treatment outcomes. ...

Signal Integrator Function of CXXC5 in Cancer

Medicine, Oncology, Life Sciences, Cell Biology, Immunology, Genetics,
CXXC5   cell signaling   cancer   targeting therapy   epigenetic regulation   Wnt/β-catenin pathway   TGF-β/BMP pathway  

Signal Integrator Function of CXXC5 in Cancer Academic Background CXXC5 (CXXC-type zinc finger protein 5) is a member of the ZF-CXXC protein family and plays a pivotal role in signal integration and information transfer within the cellular signaling network. By regulating multiple signaling pathways (such as Wnt/β-catenin, TGF-β/BMP, ATM/p53, etc.)...

Developmental Pluripotency-Associated 4 Increases Aggressiveness of Pituitary Neuroendocrine Tumors by Enhancing Cell Stemness

Medicine, Endocrinology, Oncology, Life Sciences, Cell Biology, Genetics,
pituitary neuroendocrine tumors   cell stemness   Wnt/β-catenin signaling   Dppa4 gene   tumor aggressiveness   epigenetics   stem cell regulation  

The Oncogenic Role of Dppa4 in Pituitary Neuroendocrine Tumors Academic Background Pituitary Neuroendocrine Tumors (PitNETs) are common intracranial tumors that often exhibit hormone-secreting functions and are a significant cause of hypogonadism and infertility in humans. Although most PitNETs can be controlled through surgery and medication, some...

Global Profiling of Alternative Splicing in Non-Small Cell Lung Cancer Reveals Novel Histological and Population Differences

Medicine, Oncology, Life Sciences, Biochemistry, Genetics,
non-small cell lung cancer   alternative splicing   population differences   tumor biology   biomarkers   molecular subtypes   therapeutic targets  

Global Profiling of Alternative Splicing in Non-Small Cell Lung Cancer Reveals Novel Histological and Population Differences Academic Background Lung cancer is one of the most frequently diagnosed cancers in the United States, with non-small cell lung cancer (NSCLC) accounting for the majority of cases. Among NSCLC, lung adenocarcinoma (LUAD) and l...