Identifying behaviour-related and physiological risk factors for suicide attempts in the UK Biobank

Information Science, Artificial Intelligence, Medicine, Environmental and Public Health, Psychiatry, Neurology, Clinical Psychology, Life Sciences, Genetics,
suicide attempts   behaviour risk factors   physiological risk factors   UK Biobank   multifactor analysis  

Research Background: Suicide is a global public health challenge, but there is still significant uncertainty regarding the relationship between behavioral and physiological factors and suicide attempts (SA). Previous studies often focus on limited hypothesized factors such as mental illnesses (e.g., depression), personality and psychological traits...

Bidirectional Epigenetic Editing Reveals Hierarchies in Gene Regulation

Medicine, Life Sciences, Cell Biology, Immunology, Genetics, Biophysics,
Gene Regulation   Epigenetics   CRISPR Technology   Genetic Interactions   Transcription Factors  

Bidirectional Epigenetic Editing Reveals Hierarchies in Gene Regulation Background and Research Motivation In the human genome, the role of non-coding elements such as enhancers in gene regulation is widely recognized. However, current CRISPR interference methods still have some limitations in studying non-coding elements and genetic interactions. ...

Principled distillation of UK Biobank phenotype data reveals underlying structure in human variation

Medicine, Basic Medical Sciences, Life Sciences, Genetics,
UK Biobank   latent structure   human variation   health outcomes   genetic signal   data reduction   biological samples  

In this report, we present a detailed evaluation of a research paper published in the journal Nature Human Behaviour, titled “Principled Refinement of UK Biobank Phenotypic Data Reveals the Latent Structure of Human Variation.” The study, conducted by Caitlin E. Carey, Rebecca Shafee, Robbee Wedow, among others, was published online on XX XX, XXXX....

Development of Multiplexed Orthogonal Base Editor (MOBE) Systems

Life Sciences, Bioengineering, Genetics,
multiplex editing   orthogonal base editors   genome editing   point mutations   high-fidelity Cas9  

In recent years, with the rapid development of gene editing tools, especially the introduction of the CRISPR-Cas9 system, it has become possible to precisely modify specific DNA sequences. Currently, the introduction of single-nucleotide variants (SNVs) as a powerful tool for studying gene function and disease associations is particularly important...

Mapping Medically Relevant RNA Isoform Diversity in the Aged Human Frontal Cortex with Deep Long-Read RNA-Seq

Medicine, Basic Medical Sciences, Geriatrics, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
RNA isoforms   frontal cortex   long-read RNA sequencing   Alzheimer's disease   differential expression  

Academic Background RNA isoforms play a critical role in gene expression regulation. On average, human protein-coding genes contain over eight RNA isoforms, leading to nearly four distinct protein-coding sequences. Traditional short-read sequencing technologies, due to their limitations in read length, cannot accurately assemble and quantify RNA is...

Complete Substitution with Modified Nucleotides in Self-Amplifying RNA Suppresses the Interferon Response and Increases Potency

Life Sciences, Cell Biology, Bioengineering, Genetics,
modified nucleotides   self-amplifying RNA   interferon response   protein expression   vaccine   SARS-CoV-2  

Introduction Under the influence of the COVID-19 pandemic, mRNA vaccine technology has made significant advances. However, its short half-life and high dosage requirements have led to side effects and accessibility issues. To overcome these challenges, self-amplifying RNA (saRNA) has become a research hotspot. saRNA utilizes RNA-dependent RNA polym...