Real-World Overall Survival and Treatment Patterns by PTEN Status in Metastatic Castration-Resistant Prostate Cancer

Medicine, Medical Laboratory Science, Urology, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
PTEN   Castration-Resistant Prostate Cancer   Overall Survival   Treatment Patterns   Genomic Testing  

Overall Survival and Treatment Patterns in Metastatic Castration-Resistant Prostate Cancer Patients Based on PTEN Status Academic Background Prostate cancer is one of the most common malignant tumors among men worldwide and a leading cause of cancer-related deaths. Approximately 10%-20% of prostate cancer patients will develop castration-resistant ...

Prognostic Model for High-Grade Neuroendocrine Carcinoma of the Lung Incorporating Genomic Profiling and Poly (ADP-Ribose) Polymerase-1 Expression

Prognostic Model for High-Grade Neuroendocrine Carcinoma of the Lung Incorporating Genomic Profiling and Poly (ADP-Ribose) Polymerase-1 Expression

Medicine, Respiratory System, Oncology, Life Sciences, Biochemistry, Genetics,
High-Grade Neuroendocrine Carcinoma   Genomic Profiling   Poly (ADP-Ribose) Polymerase-1   Prognostic Model   Immunohistochemistry   Tumor Markers   Survival Analysis  

Prognostic Model of Pulmonary High-grade Neuroendocrine Carcinoma: Integrating Genomic Analysis and Poly(ADP-ribose) Polymerase-1 Expression Research Background High-grade neuroendocrine carcinoma (HGNEC) of the lung is a highly aggressive cancer with significant biological complexity. Despite its association with Notch pathway activation and inact...

High Concordance of Different Assays in the Determination of Homologous Recombination Deficiency–Associated Genomic Instability in Ovarian Cancer

High Concordance of Different Assays in the Determination of Homologous Recombination Deficiency–Associated Genomic Instability in Ovarian Cancer

Medicine, Medical Laboratory Science, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
Homologous Recombination Deficiency   Ovarian Cancer   Genomic Instability   Biomarkers   PARP Inhibitors  

Ovarian cancer is one of the most common and deadly tumor types in women. In recent years, Poly (ADP-ribose) polymerase inhibitors (PARPi) have shown encouraging clinical results in the treatment of ovarian cancer. Numerous studies have found that patients with homologous recombination deficiency (HRD) benefit more from PARPi treatment. Therefore, ...

Prospective Study of Homologous Recombination Repair Gene Mutation Prevalence in Patients with Advanced Prostate Cancer from Latin America: Challenges and Future Approaches

Medicine, Basic Medical Sciences, Geriatrics, Urology, Oncology, Life Sciences, Genetics,
homologous recombination repair   gene mutation   prostate cancer   Latin America   prospective study  

Academic Report for the Paper Titled “Prospective Study of Homologous Recombination Repair Gene Mutation Prevalence in Patients with Advanced Prostate Cancer from Latin America: Challenges and Future Approaches” Background Prostate cancer is one of the most common cancers among men in Latin America and the Caribbean (LAC). According to the 2020 Glo...

Comprehensive Genomic Analysis of Patients with Non–Small-Cell Lung Cancer Using Blood-Based Circulating Tumor DNA Assay: Findings from the BFAST Database of a Single Center in Taiwan

Medicine, Medical Laboratory Science, Hematology, Oncology, Life Sciences, Immunology, Genetics,
Non-Small-Cell Lung Cancer   Blood Test   Circulating Tumor DNA   Genomic Analysis   BFAST   Actionable Mutations  

Latest Research in Lung Cancer Genomics: Analysis of Circulating Tumor DNA Detection in Non-Small Cell Lung Cancer Background and Motivation In recent years, the treatment of non-small cell lung cancer (NSCLC) has seen significant changes due to the success of targeted therapies. The National Comprehensive Cancer Network guidelines recommend extens...

Pan-Cancer Interrogation of MUTYH Variants Reveals Biallelic Inactivation and Defective Base Excision Repair Across a Spectrum of Solid Tumors

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Biochemistry, Immunology, Genetics,
pan-cancer   MUTYH variants   biallelic inactivation   base excision repair   tumors  

Cross-Cancer Study Reveals Biallelic Inactivation of MUTYH and Base Excision Repair Defects in Different Types of Solid Tumors Research Background In daily life, cells are often exposed to endogenous and exogenous oxidative stress, originating from by-products of cellular respiration and various external compounds. MUTYH is a key component of the b...