Identification of Clonal Hematopoiesis Driver Mutations Through In Silico Saturation Mutagenesis

Information Science, Computer Science, Artificial Intelligence, Medicine, Basic Medical Sciences, Hematology, Oncology, Life Sciences, Immunology, Genetics,
clonal hematopoiesis   driver mutations   in silico saturation mutagenesis   machine learning models   oncology  

Introduction In the process of healthy hematopoiesis, a group of hematopoietic stem cells (HSC) contribute to all blood-related lineages. However, as we age, this process often leads to clonal hematopoiesis (CH), meaning the expansion of clones originating from a particular HSC, which then occupies a significant portion of blood cells and platelets...

Novel WRN Helicase Inhibitors Selectively Target Microsatellite-Unstable Cancer Cells

Medicine, Basic Medical Sciences, Medical Laboratory Science, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
WRN helicase   microsatellite instability   cancer treatment   DNA damage   biomarker analysis  

In the current field of tumor treatment, precision medicine continues to be a research hotspot and development trend. With the advancement of science and technology, we have begun to more accurately understand the characteristics of tumor cells and their dependencies for survival, in hopes of finding new therapeutic targets. Particularly, strategie...

ZNF397 Deficiency Triggers TET2-driven Lineage Plasticity and AR-targeted Therapy Resistance in Prostate Cancer

ZNF397 Deficiency Triggers TET2-driven Lineage Plasticity and AR-targeted Therapy Resistance in Prostate Cancer

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
Prostate Cancer   Therapy Resistance   Lineage Plasticity   ZNF397   TET2  

ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer Academic Background and Research Motivation Existing research evidence suggests that cancer cell lineage plasticity and epigenetic reprogramming enable them to evade lineage-dependent targeted therapy by adopting lineage plasticity. Howev...

Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors

Medicine, Respiratory System, Oncology, Life Sciences, Biochemistry, Genetics,
MET   kinase domain   point mutation   lung cancer   malignancies   targeted therapy  

This study reveals a new targetable cancer subtype characterized by activating point mutations in the MET tyrosine kinase domain (TKD). Researchers identified MET TKD activating mutations in approximately 0.5% of patients across a genomic data set of over 600,000 cancer cases, encompassing various tumor types, with the highest prevalence in renal c...

Iron-(Fe3+)-Dependent Reactivation of Telomerase Drives Colorectal Cancers

Iron-(Fe3+)-Dependent Reactivation of Telomerase Drives Colorectal Cancers

Medicine, Gastroenterology, Oncology, Life Sciences, Biochemistry, Genetics,
iron   telomerase   colorectal cancer   reactivation   red meat   cancer mechanism   drug target  

Iron (Ferric Ion, Fe3+)-Dependent Telomerase Reactivation Drives Colorectal Cancer Development I. Research Background Colorectal Cancer (CRC) is the third most common cancer globally, involving both genetic and non-genetic factors in its pathogenesis. Existing research shows a significant association between high iron content, hereditary iron overl...

Identifying behaviour-related and physiological risk factors for suicide attempts in the UK Biobank

Information Science, Artificial Intelligence, Medicine, Environmental and Public Health, Psychiatry, Neurology, Clinical Psychology, Life Sciences, Genetics,
suicide attempts   behaviour risk factors   physiological risk factors   UK Biobank   multifactor analysis  

Research Background: Suicide is a global public health challenge, but there is still significant uncertainty regarding the relationship between behavioral and physiological factors and suicide attempts (SA). Previous studies often focus on limited hypothesized factors such as mental illnesses (e.g., depression), personality and psychological traits...