Unraveling Glycosphingolipid Metabolism in Neuroblastic Tumors Using Transcriptome-Weighted Network Analysis

Medicine, Oncology, Life Sciences, Biochemistry,
glycosphingolipid metabolism   neuroblastic tumors   GD2   reaction activity score   metabolic network   ganglioneuroma   ganglioneuroblastoma  

Transcriptome-Weighted Network Analysis of Glycosphingolipid Metabolism in Neuroblastoma Background Introduction Glycosphingolipids (GSLs) are a class of membrane lipids composed of a ceramide backbone linked to glycan moieties, widely present in the nervous system. They play crucial roles in cell signaling, cell-cell interactions, and tumorigenesi...

Real-Time Assessment of Relative Mitochondrial ATP Synthesis Response Against Inhibiting and Stimulating Substrates (MitoRaise)

Medicine, Oncology, Life Sciences, Biochemistry,
Relative mitochondrial ATP synthesis rate   Mitochondrial function   ATP   mtDNA copy number   MitoRaise  

Real-Time Assessment of Mitochondrial ATP Synthesis Response: MitoRaise Academic Background Mitochondria are the energy factories within cells, primarily synthesizing adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS). ATP serves as the main energy carrier in cells, and its synthesis rate directly reflects the functional status...

CYP19A1 Regulates Chemoresistance in Colorectal Cancer Through Modulation of Estrogen Biosynthesis and Mitochondrial Function

Medicine, Endocrinology, Gastroenterology, Oncology, Life Sciences, Biochemistry,
colorectal cancer   chemotherapy resistance   CYP19A1   mitochondria   mitochondrial respiratory chain complexes  

CYP19A1 Regulates Chemoresistance in Colorectal Cancer through Modulation of Estrogen Biosynthesis and Mitochondrial Function Background Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide. Despite significant advances in early detection and treatment strategies, chemoresistance remains a major obstacle to eff...

Rhof Promotes Snail1 Lactylation by Enhancing PKM2-Mediated Glycolysis to Induce Pancreatic Cancer Cell Endothelial–Mesenchymal Transition

Medicine, Oncology, Life Sciences, Biochemistry,
Pancreatic Cancer   Rhof   Endothelial–Mesenchymal Transition   Glycolysis   Snail1 Lactylation  

RhoF Promotes Snail1 Lactylation by Enhancing PKM2-Mediated Glycolysis to Induce Pancreatic Cancer Cell Endothelial–Mesenchymal Transition Academic Background Pancreatic cancer (PC) is a highly malignant tumor characterized by late diagnosis, strong invasiveness, and resistance to systemic therapy, leading to poor patient prognosis. Despite recent ...

Nonemissive Iridium(III) Solvent Complex as a Self-Reporting Photosensitizer for Monitoring Phototherapeutic Efficacy in a 'Signal On' Mode

Chemistry, Analytical Chemistry, Medicinal Chemistry, Medicine, Oncology, Life Sciences, Biochemistry,
Iridium(III) solvent complex   Self-reporting photosensitizer   Phototherapeutic efficacy   Signal on   Immunogenic cell death  

Iridium(III) Solvent Complex as a Self-Reporting Photosensitizer for Monitoring Phototherapeutic Efficacy Academic Background Cancer is one of the leading causes of global mortality, significantly impacting patients’ quality of life. In recent years, photodynamic therapy (PDT) has garnered considerable attention as a promising technology for cancer...