Combination of Biological Aging and Genetic Susceptibility Helps Identifying At-Risk Population of Venous Thromboembolism: A Prospective Cohort Study of 394,041 Participants

Medicine, Geriatrics, Hematology, Cardiovascular System, Life Sciences, Genetics,
biological aging   phenotypic age   polygenic risk score   risk stratification   venous thromboembolism  

Combining Biological Aging and Genetic Susceptibility to Identify High-Risk Populations for Venous Thromboembolism Academic Background Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is the third most fatal cardiovascular disease globally. The incidence of VTE is closely related to age, particularly i...

Robust Acute Myeloid Leukemia Engraftment in Humanized Scaffolds Using Injectable Biomaterials and Intravenous Xenotransplantation

Medicine, Hematology, Oncology, Life Sciences, Bioengineering,
Acute Myeloid Leukemia   Biomaterials   Xenotransplantation   Bone Marrow Niche   Collagen   Mouse Model   Patient-Derived Xenografts  

Robust Engraftment of Acute Myeloid Leukemia (AML) in Humanized Scaffolds Background Acute myeloid leukemia (AML) is a malignant blood disorder that poses significant challenges in treatment and research. Patient-derived xenograft (PDX) models are crucial tools for studying AML, but existing PDX models are often complex and labor-intensive, limitin...

Polymorphic Single-Nucleotide Variants in miRNA Genes and the Susceptibility to Colorectal Cancer: Combined Evaluation by Pairwise and Network Meta-Analysis, Thakkinstian's Algorithm and FPRP Criterium

Medicine, Oncology, Life Sciences, Biochemistry, Genetics,
colorectal cancer   miRNA   single-nucleotide polymorphism   network meta-analysis   Thakkinstian's algorithm   false positive report probability   susceptibility  

Association Study of Polymorphic Single-Nucleotide Variants in miRNA Genes and Colorectal Cancer Susceptibility Academic Background Colorectal cancer (CRC) is one of the most common malignancies with high incidence and mortality rates worldwide. According to global cancer statistics in 2022, CRC ranks as the third most prevalent cancer, with over 1...

Predicting Outcomes in Esophageal Squamous Cell Carcinoma Using scRNA-seq and Bulk RNA-seq: A Model Development and Validation Study

Medicine, Oncology, Life Sciences, Cell Biology, Immunology,
Esophageal squamous cell carcinoma   Glucose metabolism   Immune infiltration   Prognosis   Single-cell RNA sequencing   Bulk RNA sequencing   Bioinformatics  

Prognostic Prediction Model for Esophageal Squamous Cell Carcinoma Based on Single-Cell RNA Sequencing and Bulk RNA Sequencing Research Background Esophageal Squamous Cell Carcinoma (ESCC) is one of the most common malignant tumors globally, particularly prevalent in East Asia. Despite existing treatment methods such as surgery, endoscopic resectio...

Causal Relationship Between Intestinal Microbiota, Inflammatory Cytokines, Peripheral Immune Cells, Plasma Metabolome and Parkinson's Disease: A Mediation Mendelian Randomization Study

Medicine, Neurology, Life Sciences, Biochemistry, Microbiology,
intestinal microbiota   inflammatory cytokines   mendelian randomization study   Parkinson's disease   peripheral immune cells   plasma metabolome   mediation analysis  

Causal Relationship Between Gut Microbiota and Parkinson’s Disease Academic Background Parkinson’s Disease (PD) is a common neurodegenerative disorder characterized by motor dysfunction (such as bradykinesia, muscle rigidity, and resting tremors) and non-motor symptoms (such as olfactory impairment, cognitive decline, and sleep disturbances). Altho...