New Discoveries in Astrocyte Regulation of Behavior: Application of the AstroLight Tool Academic Background For a long time, neuroscience research has primarily focused on neuronal activity, while neglecting the role of astrocytes in brain function. Although astrocytes are one of the most numerous cell types in the brain, they have traditionally be...

NOMPC Ion Channel Hinge Forms Gating Spring to Initiate Mechanosensation Academic Background Mechanosensation is the process by which organisms perceive external mechanical stimuli and convert them into electrical signals. This process plays a crucial role in touch, hearing, gravity perception, and the movement of internal organs and limbs. The ini...

Pathological Link Between Kidney Disease and Parkinson’s Disease Academic Background Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by the abnormal aggregation of α-synuclein (α-syn) in the brain, forming Lewy bodies (LBs) and Lewy neurites (LNs). In recent years, increasing evidence suggests that the pathological agg...

Neural Mechanisms and Relational Learning: Rapid Knowledge Reassembly in Neural Networks Background Humans and animals possess a remarkable ability to learn relationships between items in experience (such as stimuli, objects, and events), enabling structured generalization and rapid information assimilation. A fundamental type of such relational le...

Aberrant Splicing in Huntington’s Disease Accompanies Disrupted TDP-43 Activity and Altered m6A RNA Modification Academic Background Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms. The disease is caused by a CAG repeat expansion in the HTT gene, leading to ab...