Early Detection of Uveal Melanoma Using Electrical Impedance Spectroscopy Academic Background Uveal Melanoma (UM) is the most common primary intraocular malignancy in adults, characterized by high aggressiveness, which can lead to vision loss and even life-threatening outcomes. Early detection and timely treatment are crucial for preserving vision ...

Resolving Native GABAA Receptor Structures from the Human Brain: A Breakthrough Study Academic Background GABAA receptors (γ-aminobutyric acid type A receptors) are among the most important inhibitory neurotransmitter receptors in the brain, responsible for regulating fast inhibitory signaling in neurons. These receptors are not only key drug targe...

Genomic Research on Bipolar Disorder Background Introduction Bipolar Disorder (BD) is a severe mental illness that significantly contributes to the global disease burden. Despite its high heritability (60-80%), the majority of its genetic basis remains unclear. Previous studies have primarily focused on European populations, with limited exploratio...

Spatiotemporal Imprinting of Tissue-Resident Memory CD8 T Cell Diversity Background Tissue-resident memory CD8 T cells (TRM cells) provide long-term immune protection at barrier sites such as the intestine. However, the heterogeneity of TRM cells and the mechanisms underlying their formation remain incompletely understood. Previous studies have ide...

The Impact of the Maternal X Chromosome on Cognition and Brain Aging in Female Mice Background Introduction In mammals, female cells possess two X chromosomes, one from the mother (maternal X chromosome, Xm) and one from the father (paternal X chromosome, Xp). During embryonic development, one of the X chromosomes is randomly inactivated, a process...