Multiscale Footprints Reveal the Organization of Cis-Regulatory Elements

Information Science, Artificial Intelligence, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
cis-regulatory elements   chromatin accessibility   transcription factors   deep learning   single-cell sequencing   genomics   cell differentiation  

Multiscale Footprints Reveal the Role of Cis-Regulatory Elements in Cell Differentiation and Aging Background Introduction The regulation of gene expression is a key mechanism in cell fate determination and disease development, and cis-regulatory elements (CREs) play a crucial role in this process. CREs dynamically regulate gene expression by bindi...

Leveraging a Phased Pangenome for Haplotype Design of Hybrid Potato

Life Sciences, Genetics, Botany,
potato   pangenome   haplotype design   hybrid breeding   structural variants   deleterious mutations   genomic diversity  

Leveraging a Phased Pangenome for Haplotype Design of Hybrid Potato Academic Background Potato (Solanum tuberosum L.) is one of the most important tuber crops globally, providing food for over 1.3 billion people annually across more than 120 countries. However, the tetraploid genome and clonal propagation of potatoes result in slow breeding progres...

Rapid and Scalable Personalized ASO Screening in Patient-Derived Organoids

Medicine, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
personalized therapeutics   antisense oligonucleotides   rare diseases   organoid models   gene therapy   Duchenne muscular dystrophy   stem cells  

Establishment of a Personalized Antisense Oligonucleotide (ASO) Screening Platform Based on Patient-Derived Organoids Academic Background In recent years, with the rapid development of genome sequencing technologies, an increasing number of rare genetic diseases have been found to be associated with specific gene mutations. Antisense oligonucleotid...

Optimization-Based Conformal Path Planning for In Situ Bioprinting During Complex Skin Defect Repair

Engineering, Mechanical Engineering, Medicine, Life Sciences, Bioengineering,
in situ bioprinting   path planning   robot control   skin injury repair   conformal slicing   optimization algorithm   tissue engineering  

Optimization-Based Conformal Path Planning for In Situ Bioprinting in Complex Skin Defect Repair Academic Background The skin, as the largest organ in the human body, plays a crucial role in protecting the body from external harm. However, the high prevalence of skin injuries such as burns and chronic ulcers worldwide has led to an increasing deman...

Concurrently Bioprinted Scaffolds with Autologous Bone and Allogeneic BMSCs Promote Bone Regeneration through Native BMSC Recruitment

Medicine, Orthopedics, Neurosurgery, Life Sciences, Bioengineering,
bone regeneration   3D bioprinting   autologous bone particles   allogeneic mesenchymal stem cells   cranioplasty  

Research on 3D Bioprinted Scaffolds Promoting Bone Regeneration Academic Background In recent years, the incidence of head and craniofacial injuries has significantly increased due to the development of industries and transportation, as well as the frequent occurrence of wars and conflicts. These injuries and related treatments (such as decompressi...