METTL3 Promotes Osteogenesis by Regulating N6-Methyladenosine-Dependent Primary Processing of hsa-mir-4526

Medicine, Orthopedics, Basic Medical Sciences, Oral Sciences, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
METTL3   osteogenesis   N6-methyladenosine   miRNA processing   hsa-mir-4526   adipose stem cells   bone repair  

New Mechanism of m6A Methylation Promoting Osteogenic Differentiation of Adipose-Derived Stem Cells Revealed — Study Based on METTL3-Mediated Primary microRNA Splicing Regulation of hsa-mir-4526 1. Academic Background and Research Motivation Bone tissue engineering has emerged as a cutting-edge interdisciplinary research field due to rapid advances...

PDGFR Marks Distinct Mesenchymal and Pericyte Populations Within the Periosteum With Overlapping Cellular Features

Medicine, Orthopedics, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
periosteum   PDGFRβ   mesenchymal progenitor cells   pericytes   bone regeneration   single-cell RNA sequencing  

New Developments in Bone Regeneration: The Discovery of PDGFRβ-marked Distinct Mesenchymal and Pericyte Subpopulations in the Periosteum — Interpretation of “pdgfr marks distinct mesenchymal and pericyte populations within the periosteum with overlapping cellular features” 1. Research Background and Scientific Question The periosteum, a thin vascul...

A self-assembling surface layer flattens the cytokinetic furrow to aid cell division in an archaeon

Life Sciences, Cell Biology, Biochemistry, Bioengineering, Biophysics, Microbiology,
self-assembly   surface layer   cell division   archaea   S-layer   membrane deformation   cell mechanics  

1. Academic Background Since the origin of life, living organisms have needed to construct effective barriers to protect their cells from external physical and chemical damage. In the realms of bacteria and archaea, the surface layer (S-layer) is a universally present and exquisitely structured two-dimensional protein lattice that substitutes for t...

Monocytes Use Protrusive Forces to Generate Migration Paths in Viscoelastic Collagen-Based Extracellular Matrices

Medicine, Oncology, Life Sciences, Cell Biology, Bioengineering, Immunology, Biophysics,
monocyte   cell migration   extracellular matrix   viscoelasticity   tumor microenvironment   collagen   protrusive force  

New Mechanism of Immune Cell Migration Revealed: How Monocytes “Pioneer Their Path” in the Tumor Microenvironment I. Academic Research Background and the Central Question Cell migration is a crucial biological process in life, encompassing embryonic development, tissue repair, immune responses, and the progression of various diseases. In the contex...

Continuous self-repair protects vimentin intermediate filaments from fragmentation

Life Sciences, Cell Biology, Biochemistry, Bioengineering, Biophysics,
intermediate filaments   vimentin   cytoskeleton   subunit exchange   self-repair   fragmentation mechanism  

Academic Background and Research Motivation The cytoskeleton is the core structural support responsible for maintaining cell morphology and mechanical properties and is mainly composed of three major classes: actin filaments, microtubules, and intermediate filaments. Among these, intermediate filaments play an irreplaceable role in maintaining cell...

Single Antisense Oligonucleotides Correct Diverse Splicing Mutations in Hotspot Exons

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
antisense oligonucleotide   splicing mutation   hotspot exon   RNA splicing   actionable genes   gene mutation   therapeutic strategy  

Broad-Spectrum Correction of Splicing Mutations in Rare Disease Hotspot Exons by Single Antisense Oligonucleotide: Review of a Recent 2025 PNAS Study I. Academic Background: The Challenge of Disease-Associated Splicing Mutations and Dilemmas in Antisense Therapy RNA splicing is a crucial step in the regulation of gene expression in eukaryotes. The ...