Inflammatory Pathways and the Bone Marrow Microenvironment in Inherited Bone Marrow Failure Syndromes

Medicine, Pediatrics, Basic Medical Sciences, Hematology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
inherited bone marrow failure syndromes   inflammation   pro-inflammatory cytokines   bone marrow microenvironment   mesenchymal stromal cells   hematopoietic stem cells   cytokine network  

Inflammatory Pathways and Bone Marrow Microenvironment in Inherited Bone Marrow Failure Syndromes: New Insights into Chronic Inflammation Research Background and Academic Significance Inherited bone marrow failure syndromes (IBMFS) are a group of genetic disorders characterized by reduced hematopoietic cell production due to blood stem cell dysfunc...

RUNX1 is a Key Inducer of Human Hematopoiesis Controlling Non-Hematopoietic Mesodermal Development

Medicine, Basic Medical Sciences, Hematology, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
RUNX1   hematopoiesis   non-hematopoietic mesoderm   mesenchymal cells   transcription factor   human development   stem cell differentiation  

The Dominant Role of RUNX1 in Human Hematopoietic Development and Mesodermal Fate Balance — An Interpretation of “runx1 is a key inducer of human hematopoiesis controlling non-hematopoietic mesodermal development” 1. Academic Background and Research Motivation The development of the hematopoietic system is fundamental for the growth and maintenance...

Adult Human Heart Extracellular Matrix Improves Human iPSC-CM Function via Mitochondrial and Metabolic Maturation

Medicine, Basic Medical Sciences, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
extracellular matrix   iPSC-derived cardiomyocyte   functional maturation   mitochondrial maturation   metabolic maturation   cell therapy  

1. Academic Background Cardiovascular diseases, especially myocardial infarction (MI), are among the leading causes of death and disability worldwide. After a myocardial infarction, up to one billion cardiomyocytes (CM) can be lost in just a few hours. However, adult myocardial tissue itself has extremely low regenerative capacity, which means the ...

Neonatal Apical Resection Preserves the Proliferative Capacity of Cardiomyocytes Throughout the Left Ventricle

Medicine, Basic Medical Sciences, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
apical resection   cardiomyocyte   cell-cycle   heart regeneration   heat shock protein   left ventricle   pig model  

I. Academic Background: The Cardiac Mystery Facing Regenerative Medicine Cardiovascular diseases, especially myocardial infarction (MI), are among the leading causes of death and disability worldwide due to heart damage. However, the adult mammalian heart has long been regarded as having essentially lost its endogenous regenerative ability, with th...

Renal Protective Effects of Extracellular Vesicle-Encapsulated Tumor Necrosis Factor-α-Induced Protein 6 Derived from Mesenchymal Stem Cells

Medicine, Basic Medical Sciences, Nephrology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology,
mesenchymal stem cells   inflammation   renal protection   extracellular vesicles   TNF-α-induced protein 6   M2 macrophage polarization   regulatory T cells  

I. Research Background and Academic Significance In recent years, the incidence of acute kidney injury (AKI) has been continuously rising worldwide. AKI not only leads to acute loss of renal function but is increasingly recognized as being closely related to the occurrence and progression of chronic kidney disease (CKD). Numerous epidemiological an...

METTL3 Promotes Osteogenesis by Regulating N6-Methyladenosine-Dependent Primary Processing of hsa-mir-4526

Medicine, Orthopedics, Basic Medical Sciences, Oral Sciences, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
METTL3   osteogenesis   N6-methyladenosine   miRNA processing   hsa-mir-4526   adipose stem cells   bone repair  

New Mechanism of m6A Methylation Promoting Osteogenic Differentiation of Adipose-Derived Stem Cells Revealed — Study Based on METTL3-Mediated Primary microRNA Splicing Regulation of hsa-mir-4526 1. Academic Background and Research Motivation Bone tissue engineering has emerged as a cutting-edge interdisciplinary research field due to rapid advances...