Single Antisense Oligonucleotides Correct Diverse Splicing Mutations in Hotspot Exons

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
antisense oligonucleotide   splicing mutation   hotspot exon   RNA splicing   actionable genes   gene mutation   therapeutic strategy  

Broad-Spectrum Correction of Splicing Mutations in Rare Disease Hotspot Exons by Single Antisense Oligonucleotide: Review of a Recent 2025 PNAS Study I. Academic Background: The Challenge of Disease-Associated Splicing Mutations and Dilemmas in Antisense Therapy RNA splicing is a crucial step in the regulation of gene expression in eukaryotes. The ...

Intermediate Light Adaptation Induces Oscillatory Phototaxis Switching and Pattern Formation in Chlamydomonas

Physics, Fluid Physics, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Biophysics, Botany, Microbiology,
Chlamydomonas   phototaxis   light adaptation   flagellar beating   microswimmers   behavioral switching   pattern formation  

Light Adaptation Drives New Motility Patterns in Green Algae — A Review of “Intermediate light adaptation induces oscillatory phototaxis switching and pattern formation in Chlamydomonas” 1. Research Background and Scientific Questions Microswimmers at the microscopic scale, such as unicellular algae, bacteria, and sperm, are important ecological co...

Pathogenic Variants in the Polycystin Pore Helix Cause Distinct Forms of Channel Dysfunction

Medicine, Basic Medical Sciences, Nephrology, Life Sciences, Cell Biology, Biochemistry, Genetics, Biophysics,
autosomal dominant polycystic kidney disease   polycystin   PKD2   ion channels   cryo-EM   channel dysfunction   protein assembly  

Molecular Mechanism Analysis of ADPKD Pathogenic Variants in Ion Channels – In-depth Interpretation of PNAS 2025 Latest Original Research I. Academic Research Background and Scientific Significance Autosomal Dominant Polycystic Kidney Disease (ADPKD) is one of the most common monogenic disorders worldwide, affecting millions of individuals. The pat...

Generative Prediction of Causal Gene Sets Responsible for Complex Traits

Information Science, Artificial Intelligence, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
gene regulatory networks   complex traits   generative deep learning   variational autoencoder   causal gene sets   phenotypic variation   polygenic diseases  

Generative Deep Learning for Predicting Causal Gene Sets of Complex Traits: PNAS Landmark New Method Explained I. Academic Background and Research Motivation The Dilemma of Complex Traits The relationship between genotype and phenotype has long been one of the core issues in biology and genetics. This challenge is especially prominent in the study ...

Intermediate Light Adaptation Induces Oscillatory Phototaxis Switching and Pattern Formation in Chlamydomonas

Physics, Fluid Physics, Life Sciences, Cell Biology, Biophysics, Botany, Microbiology,
Chlamydomonas   phototaxis   light adaptation   flagella beats   microswimmers   behavioral switching   pattern formation  

New Discovery of Green Microswimmer: Oscillatory Phototaxis and Pattern Formation Induced by Light Adaptation — Review of “intermediate light adaptation induces oscillatory phototaxis switching and pattern formation in chlamydomonas” 1. Research and Academic Background Light, as a core environmental signal for living organisms, drives diverse behav...

The Dependence of Amino Acid Backbone Conformation on the Translated Synonymous Codon Is Not Statistically Significant

Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics, Biophysics,
synonymous codon   protein structure   dihedral angle   statistical analysis   protein folding   translation regulation  

Re-evaluating the Influence of Synonymous Codons on Protein Backbone Conformation — A Dialectic Under Rigorous Statistical Testing in Structural Biology 1. Academic Background and Research Motivation In the fields of molecular biology and structural biology, the relationship between codons and protein structure has long been a focal point of resear...