Real-World Overall Survival and Treatment Patterns by PTEN Status in Metastatic Castration-Resistant Prostate Cancer

Medicine, Medical Laboratory Science, Urology, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
PTEN   Castration-Resistant Prostate Cancer   Overall Survival   Treatment Patterns   Genomic Testing  

Overall Survival and Treatment Patterns in Metastatic Castration-Resistant Prostate Cancer Patients Based on PTEN Status Academic Background Prostate cancer is one of the most common malignant tumors among men worldwide and a leading cause of cancer-related deaths. Approximately 10%-20% of prostate cancer patients will develop castration-resistant ...

Plasma Proteome-Based Test for First-line Treatment Selection in Metastatic Non–Small Cell Lung Cancer

Medicine, Rheumatology and Immunology, Medical Laboratory Science, Oncology, Life Sciences, Biochemistry, Immunology,
Lung Cancer   Proteomics   Personalized Medicine   Predictive Model   Immunotherapy   Chemotherapy  

In the tumor microenvironment (Tumor Microenvironment, TME), Immune Checkpoint Inhibitors (ICIs) targeting PD-1 or PD-L1 enhance the body’s natural ability to eliminate cancer cells by disrupting the inhibitory receptor-ligand interaction. However, even so, critical trials indicate that the response rate for monotherapy is <50%, with a median Progr...

Prognostic Model for High-Grade Neuroendocrine Carcinoma of the Lung Incorporating Genomic Profiling and Poly (ADP-Ribose) Polymerase-1 Expression

Prognostic Model for High-Grade Neuroendocrine Carcinoma of the Lung Incorporating Genomic Profiling and Poly (ADP-Ribose) Polymerase-1 Expression

Medicine, Respiratory System, Oncology, Life Sciences, Biochemistry, Genetics,
High-Grade Neuroendocrine Carcinoma   Genomic Profiling   Poly (ADP-Ribose) Polymerase-1   Prognostic Model   Immunohistochemistry   Tumor Markers   Survival Analysis  

Prognostic Model of Pulmonary High-grade Neuroendocrine Carcinoma: Integrating Genomic Analysis and Poly(ADP-ribose) Polymerase-1 Expression Research Background High-grade neuroendocrine carcinoma (HGNEC) of the lung is a highly aggressive cancer with significant biological complexity. Despite its association with Notch pathway activation and inact...

High Concordance of Different Assays in the Determination of Homologous Recombination Deficiency–Associated Genomic Instability in Ovarian Cancer

High Concordance of Different Assays in the Determination of Homologous Recombination Deficiency–Associated Genomic Instability in Ovarian Cancer

Medicine, Medical Laboratory Science, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
Homologous Recombination Deficiency   Ovarian Cancer   Genomic Instability   Biomarkers   PARP Inhibitors  

Ovarian cancer is one of the most common and deadly tumor types in women. In recent years, Poly (ADP-ribose) polymerase inhibitors (PARPi) have shown encouraging clinical results in the treatment of ovarian cancer. Numerous studies have found that patients with homologous recombination deficiency (HRD) benefit more from PARPi treatment. Therefore, ...

Pan-Cancer Interrogation of MUTYH Variants Reveals Biallelic Inactivation and Defective Base Excision Repair Across a Spectrum of Solid Tumors

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Biochemistry, Immunology, Genetics,
pan-cancer   MUTYH variants   biallelic inactivation   base excision repair   tumors  

Cross-Cancer Study Reveals Biallelic Inactivation of MUTYH and Base Excision Repair Defects in Different Types of Solid Tumors Research Background In daily life, cells are often exposed to endogenous and exogenous oxidative stress, originating from by-products of cellular respiration and various external compounds. MUTYH is a key component of the b...

Genomic Profiling of Rare Undifferentiated Sarcomatoid Subtypes of Pancreatic Carcinomas: In Search of Therapeutic Targets

Medicine, Medical Laboratory Science, Oncology, Life Sciences, Biochemistry, Immunology,
Undifferentiated Sarcomatoid Carcinoma   Pancreatic Cancer   Genomic Profiling   Therapeutic Targets   Immune Checkpoint Inhibitors  

Genomic Characteristics of a Rare Pancreatic Cancer Undifferentiated Sarcomatoid Carcinoma Subtype Academic Background Pancreatic Ductal Adenocarcinoma (PDAC) is one of the deadliest cancers, characterized by early invasion and metastasis. Undifferentiated Sarcomatoid Carcinoma (USC) is a particularly aggressive but rare subtype of PDAC, accounting...