Regulation of Neuroinflammation and Demyelination by Cystatin F Following Murine Coronavirus Infection of the Central Nervous System

Medicine, Infectious Diseases, Basic Medical Sciences, Neurology, Neurosurgery, Life Sciences, Biochemistry, Immunology,
Cystatin F   neuroinflammation   demyelination   murine coronavirus   central nervous system   immune response  

The Role of Cystatin F in Regulating Neuroinflammation and Demyelination in Spinal Cord Poliovirus Infection Background Knowledge Cystatin F is a secreted lysosomal cysteine protease inhibitor associated with every stage of virus-related neurological diseases, including host defense, demyelination, and myelination. However, research on how Cystatin...

Genome-Wide Loss of Heterozygosity Predicts Aggressive, Treatment-Refractory Behavior in Pituitary Neuroendocrine Tumors

Medicine, Endocrinology, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
aggressive pituitary tumor   treatment-refractory pituitary tumor   pituitary carcinoma   pituitary neuroendocrine tumor   loss of heterozygosity   biomarker  

Prediction of Invasiveness and Treatment Resistance Behavior of Pituitary Neuroendocrine Tumors Based on Genome-Wide Loss of Heterozygosity Background: Pituitary neuroendocrine tumors (PitNETs) are mostly benign, but a small portion exhibit invasive and treatment-resistant behaviors, continuing to grow or metastasize even after surgery, conventiona...

Aberrant CHCHD2-Associated Mitochondriopathy in Kii ALS/PDC Astrocytes

Medicine, Medical Laboratory Science, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
ALS   PDC   Kii ALS/PDC   CHCHD2   astrocytes   mitochondria  

Study Report on Abnormal CHCHD2-Related Mitochondrial Pathology in Astrocytes in Kii ALS/PDC I. Research Background Amyotrophic lateral sclerosis/Parkinsonism-dementia complex (ALS/PDC) is a rare and complex neurodegenerative disorder primarily observed in Western Pacific islands such as Japan, Guam, and Papua New Guinea. Patients with this disease...

Co-registration of MALDI-MSI and histology demonstrates gangliosides co-localize with amyloid beta plaques in Alzheimer’s disease

Co-registration of MALDI-MSI and histology demonstrates gangliosides co-localize with amyloid beta plaques in Alzheimer’s disease

Medicine, Medical Laboratory Science, Neurology, Medical Imaging, Life Sciences, Biochemistry, Immunology,
Alzheimer's disease   gangliosides   lipids   MALDI-MSI   digital pathology  

Co-localization of Gangliosides with Amyloid Beta Plaques in Alzheimer’s Disease Detected by MALDI-MSI and Histology Alzheimer’s Disease (AD) is a progressive neurodegenerative disease characterized by cognitive impairment and behavioral changes. Historically, AD research has focused on misfolded proteins, but with advancements in mass spectrometry...

Annexin A11 Aggregation in FTLD-TDP Type C and Related Neurodegenerative Disease Proteinopathies

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
neurodegenerative disease   TDP-43   FTLD-TDP   ALS   Annexin A11  

Study on Annexin A11 Aggregation and TDP-43 Proteinopathies in Neurodegenerative Diseases In this research report published in Acta Neuropathologica, researchers led by John L. Robinson from the University of Pennsylvania investigate the aggregation phenomena of Annexin A11 in neurodegenerative diseases, particularly in FTLD-TDP Type C, which is as...

Clinically Unfavorable Transcriptome Subtypes of Non-WNT/Non-SHH Medulloblastomas are Associated with a Predominance in Proliferating and Progenitor-Like Cell Subpopulations

Medicine, Pediatrics, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry,
medulloblastoma   non-WNT   non-SHH   subgroups   deconvolution   prognosis  

Association of Adverse Transcriptomic Subtypes of Non-WNT/Non-SHH Medulloblastoma with the Dominance of Proliferative and Progenitor-like Subpopulations Research Background Medulloblastoma (MB) is one of the most common malignant tumors of the central nervous system in children. Based on molecular characteristics, the medical community typically cl...