Scientific Report: Study Reveals the Role of SMARCA4 in B Cell Lymphoma Background Introduction The germinal center (GC) plays a crucial role in the maturation and apoptosis of B cells. The GC reaction is a rapid and transient immune response structure that improves the affinity of B cells to specific antigens through somatic mutation and affinity ...
The Biological Basis of Regional ECM Breakdown and Nerve Invasion in Pancreatic Cancer Background Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most aggressive types of cancer, typically associated with a highly fibrotic stroma, which can account for about 90% of the tumor mass. Although morphological heterogeneity is not addressed in routi...
Dendritic-cell-targeting Virus-like Particles as Potent mRNA Vaccine Carriers Introduction In vaccine development, especially mRNA vaccines, significant achievements have been made in recent years. The mRNA vaccines developed by Moderna and Pfizer/BioNTech against COVID-19 have set a successful precedent, greatly advancing the development of mRNA v...
The Application of Antibodies Displaying Extracellular Vesicles in Targeted Cancer Therapy Extracellular Vesicles (EVs) have been extensively researched as natural delivery carriers and mediators of biological signals in various tissues. In this study, researchers utilized these characteristics of EVs to demonstrate a modular delivery system for ca...
Spatial Multi-omics High Throughput In Situ Pairwise Sequencing at Subcellular Resolution Research Background and Objectives With the continuous advancement in biomedical research, the application of multi-omics technologies in understanding cell functions and disease mechanisms has gained increasing attention. However, many current in situ sequenc...
Precise Colorectal Cancer Screening Based on Customized Intervals Using Fecal Hemoglobin Concentration Researchers: Amy Ming-Fang Yen, Yang-Ching Chen, Yu-Lin Ding, Wen-Zhu Qiu, Han-Mo Qiu, Tony Hsiu-Hsi Chen, Sam Li-Sheng Chen Academic Background Colorectal cancer (CRC) is the third most prevalent malignancy worldwide. In recent years, significant...