PRMT5-Regulated Splicing of DNA Repair Genes Drives Chemoresistance in Breast Cancer Stem Cells Academic Background Breast Cancer Stem Cells (BCSCs) are a rare subpopulation of cells within breast cancer that possess the ability to self-renew, initiate tumors, and metastasize. Despite their critical role in tumor initiation and progression, the mec...

Mitochondrial Unfolded Protein Response-Dependent β-Catenin Signaling Promotes Neuroendocrine Prostate Cancer Academic Background Prostate cancer is the second most commonly diagnosed cancer in American men, second only to skin cancer. Although current treatments, such as androgen deprivation therapy (ADT), can induce remission in prostate cancer, ...

Academic Background and Paper Introduction Background The Wnt/β-catenin signaling pathway is dysregulated in various cancers, particularly in colorectal and endometrial cancers. Abnormal activation of this pathway is often associated with mutations in tumor suppressor genes such as APC, AXIN1/2, and β-catenin itself. Additionally, RNF43 and ZNRF3, ...

Academic Background and Problem Statement Gastric Cancer (GC) is one of the most common cancers worldwide, with approximately 1.1 million new cases diagnosed in 2020. Although advancements in early detection, surgical techniques, and oncology have led to a decline in GC mortality, the treatment of advanced or metastatic GC remains a significant cha...

TRIB3 Promotes Multiple Myeloma Progression by Stabilizing SSRP1 via USP10-Mediated Deubiquitination Academic Background Multiple Myeloma (MM) is the second most common hematologic malignancy globally, characterized by aggressive progression, frequent relapse, and resistance to therapy. Although current multi-drug combination therapies have signifi...

lgals9b Stabilizes eef1d Protein and Activates the PI3K/AKT Signaling Pathway to Promote Gastric Cancer Occurrence and Metastasis Academic Background Gastric cancer ranks as the fifth most prevalent cancer globally, with over one million new cases diagnosed annually. Due to late detection, it exhibits a high mortality rate and is the fourth leading...