Design of a Magnetic Nanoplatform Based on CD26 Targeting and HSP90 Inhibition for Apoptosis and Ferroptosis-Mediated Elimination of Senescent Cells

Design of a Magnetic Nanoplatform Based on CD26 Targeting and HSP90 Inhibition for Apoptosis and Ferroptosis-Mediated Elimination of Senescent Cells

Chemistry, Nanoscience, Medicinal Chemistry, Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology,
Iron oxide nanoparticles   CD26   HSP90 inhibitor   Drug-induced senescence   Skin cells   Senolysis  

Magnetic Nanoplatform Based on CD26 Targeting and HSP90 Inhibition for Apoptosis and Ferroptosis-Mediated Elimination of Senescent Cells Academic Background With the intensification of population aging, the accumulation of senescent cells is considered a significant hallmark of aging and age-related diseases. Senescent cells are not only associated...

Enhancing Gene Delivery to Breast Cancer with Highly Efficient siRNA Loading and pH-Responsive Small Extracellular Vesicles

Enhancing Gene Delivery to Breast Cancer with Highly Efficient siRNA Loading and pH-Responsive Small Extracellular Vesicles

Chemistry, Medicinal Chemistry, Chemical Engineering, Medicine, Oncology, Life Sciences, Biochemistry, Bioengineering, Genetics,
small extracellular vesicles   gene delivery   pH-responsive   graphene quantum dots   lysosomal escape   breast cancer   siRNA  

Enhancing Gene Delivery to Breast Cancer with Highly Efficient siRNA Loading and pH-Responsive Small Extracellular Vesicles Academic Background In recent years, small extracellular vesicles (sEVs) have become a hot topic in the field of drug delivery due to their natural origin and inherent homing properties. sEVs are lipid nanoparticles secreted b...

Assembly of Recombinant Proteins into β-Sheet Fibrillating Peptide-Driven Supramolecular Hydrogels for Enhanced Diabetic Wound Healing

Chemistry, Medicinal Chemistry, Medicine, Life Sciences, Biochemistry, Bioengineering,
supramolecular hydrogels   diabetic wound healing   β-sheet fibrillating peptides   recombinant proteins   cell migration   epidermal regeneration   biofunctional materials  

Supramolecular Hydrogels Driven by β-Sheet Fibrillating Peptides for Enhanced Diabetic Wound Healing Academic Background Diabetic wound healing is a global health issue. Due to microvascular complications and immune dysfunction caused by hyperglycemia, the wound healing process in diabetic patients is often severely hindered. Traditional treatments...

Dopamine Receptors D1, D2, and D4 Modulate Electrical Synapses and Excitability in the Thalamic Reticular Nucleus

Medicine, Neurology, Life Sciences, Biochemistry, Biophysics,
dopamine receptors   electrical synapses   thalamic reticular nucleus   excitability   neuromodulation  

The Regulatory Role of Dopamine Receptors in the Thalamic Reticular Nucleus: A Study on Neuronal Excitability and Electrical Synapses Academic Background The Thalamic Reticular Nucleus (TRN) is a crucial inhibitory neuronal network in the brain, responsible for regulating the transmission of sensory information between the thalamus and the cortex. ...

Recovery from Spreading Depolarization is Slowed by Aging and Accelerated by Antioxidant Treatment in Locusts

Medicine, Neurology, Life Sciences, Biochemistry, Biophysics,
spreading depolarization   aging   antioxidant   locusts   neural circuits   oxidative stress   Na+/K+-ATPase  

The Impact of Aging and Antioxidants on the Recovery from Spreading Depolarization in Locusts Academic Background Spreading Depolarization (SD) is a phenomenon that temporarily shuts down neural processing in both mammals and insects. In humans, SD is associated with various pathological states, such as migraine aura and neuronal death following tr...

APOBEC3C-mediated NF-κB Activation Enhances Clear Cell Renal Cell Carcinoma Progression

Medicine, Nephrology, Oncology, Life Sciences, Biochemistry, Immunology,
Clear cell renal cell carcinoma   APOBEC3C   NF-κB   RNA-binding protein   Tumor progression  

APOBEC3C-Mediated NF-κB Activation Enhances Clear Cell Renal Cell Carcinoma Progression Academic Background Clear cell renal cell carcinoma (CCRCC) is the most common subtype of kidney cancer, accounting for approximately 75% of all kidney cancer cases. Although immunotherapy has shown some potential in treating CCRCC, the treatment of metastatic C...