Focal Deletions of a Promoter Tether Activate the IRX3 Oncogene in T-Cell Acute Lymphoblastic Leukemia

Medicine, Hematology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
T-cell acute lymphoblastic leukemia   FTO gene   IRX3 oncogene   enhancer hijacking   CTCF binding site   noncoding genome   tumor suppressor mechanism  

Stage-specific Chromosomal Deletions Activate the IRX3 Oncogene in T-cell Acute Lymphoblastic Leukemia In the field of cancer research, understanding regulatory mechanisms of the noncoding genome remains a key focus, especially concerning how oncogenes can be aberrantly activated through non-canonical regulatory pathways. This paper, authored by Su...

Genetic and Pharmacological Targeting of mTORC1 in Mouse Models of Arteriovenous Malformation Expose Non-Cell Autonomous Signalling in HHT

Medicine, Hematology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
Hereditary Hemorrhagic Telangiectasia   Arteriovenous Malformation   Endothelial Cells   mTORC1   Signaling Pathways   Genetic Targeting   Pharmacological Treatment  

Genetic and Pharmacological Targeting of mTORC1 in Mouse Models of Arteriovenous Malformation Expose Non-Cell Autonomous Signalling in HHT Hereditary Hemorrhagic Telangiectasia (HHT) is a genetic disorder caused by mutations leading to the loss of function in either Activin Receptor-Like Kinase 1 (ACVRL1) or Endoglin (ENG), which act as receptors a...

Botulinum Neurotoxin Serotype A Inhibited Ocular Angiogenesis through Modulating Glial Activation via SOCS3

Medicine, Neurology, Ophthalmology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Botulinum Neurotoxin Serotype A   Choroidal Neovascularization   Age-Related Macular Degeneration   Glial Activation   Müller Activation   Microglial Activation   SOCS3  

Academic Background Age-related macular degeneration (AMD) is a major cause of central vision loss among the elderly, particularly in its neovascular (NV) form, where choroidal neovascularization (CNV) leads to rapid and severe vision loss. Current AMD treatments primarily rely on intravitreal injections of anti-vascular endothelial growth factor (...

The Influences of APOE Isoforms on Endothelial Adherens Junctions and Actin Cytoskeleton Responding to MCRP

Medicine, Geriatrics, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
APOE   Monomeric C-reactive protein   Endothelial cells   Cytoskeleton   Alzheimer's disease   Cerebrovascular   F-actin  

Research Background Alzheimer’s Disease (AD) is a common neurodegenerative disorder characterized by the deposition of amyloid-beta (Aβ) plaques and abnormal phosphorylation of tau protein. Recent studies have increasingly highlighted the role of cerebrovascular alterations in the pathogenesis of AD. Specifically, endothelial cell damage and inflam...

Advanced Single-Cell and Spatial Analysis with High-Multiplex Characterization of Circulating Tumor Cells and Tumor Tissue in Prostate Cancer: Unveiling Resistance Mechanisms with the CODuco In Situ Assay

Medicine, Urology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Circulating Tumor Cells (CTCs)   Metastatic Prostate Cancer   Multiplex Padlock Probe In Situ Hybridization   Single-Cell Gene Expression   Liquid Biopsy   Spatial Transcriptomics   Neuroendocrine Transdifferentiation  

Research Report on the Academic Paper Title: Advanced Single-Cell and Spatial Analysis with High-Multiplex Characterization of Circulating Tumor Cells and Tumor Tissue in Prostate Cancer: Unveiling Resistance Mechanisms with the CODuco In Situ Assay Authors: Lilli Bonstingl et al. Journal: Biomarker Research (2024) 12:140 DOI: 10.1186/s40364-024-00...

GDF15 Propeptide Promotes Bone Metastasis of Castration-Resistant Prostate Cancer by Augmenting the Bone Microenvironment

Medicine, Urology, Oncology, Life Sciences, Biochemistry,
Castration-Resistant Prostate Cancer   Bone Metastasis   GDF15   Biomarker   Bone Microenvironment  

Research Objective This study aims to identify specific proteins secreted by prostate cancer cells through comprehensive proteomic analysis and explore their role in bone metastasis, with the goal of discovering blood biomarkers that can improve the prognosis of patients with metastatic castration-resistant prostate cancer (mCRPC). Research Team an...