APOBEC3C-mediated NF-κB Activation Enhances Clear Cell Renal Cell Carcinoma Progression

Medicine, Nephrology, Oncology, Life Sciences, Biochemistry, Immunology,
Clear cell renal cell carcinoma   APOBEC3C   NF-κB   RNA-binding protein   Tumor progression  

APOBEC3C-Mediated NF-κB Activation Enhances Clear Cell Renal Cell Carcinoma Progression Academic Background Clear cell renal cell carcinoma (CCRCC) is the most common subtype of kidney cancer, accounting for approximately 75% of all kidney cancer cases. Although immunotherapy has shown some potential in treating CCRCC, the treatment of metastatic C...

WWP1 Regulates TXNIP Ubiquitination and Degradation in Acute Myeloid Leukemia Cells via Redox State Modulation

Medicine, Hematology, Oncology, Life Sciences, Biochemistry,
acute myeloid leukemia   ubiquitination   redox homeostasis   reactive oxygen species   WWP1   TXNIP   apoptosis  

WWP1 Regulates Redox State in Acute Myeloid Leukemia Cells by Modulating TXNIP Background Acute myeloid leukemia (AML) is a malignant blood disorder characterized by the abnormal proliferation of immature leukemia cells (leukemic blasts) in the bone marrow. Although significant progress has been made in the treatment of AML in recent years, the lon...

Simultaneous Detection of Eight Cancer Types Using a Multiplex Droplet Digital PCR Assay

Medicine, Oncology, Life Sciences, Biochemistry, Genetics,
cancer detection   DNA methylation   droplet digital PCR   multiplexing   biomarkers   early diagnosis   tumor prediction  

Multi-Cancer Detection Using Multiplex Droplet Digital PCR Methylation Assay Background Cancer is one of the leading causes of death worldwide, with nearly 10 million deaths reported in 2020. Although many cancers can be cured when detected and treated early, many patients are still diagnosed at advanced stages, leading to poor treatment outcomes. ...

Dynamic Methylation and Expression of Alternative Promoters for Oestrogen Receptor Alpha in Cell Line Models of Fulvestrant Resistance

Medicine, Endocrinology, Oncology, Life Sciences, Biochemistry,
breast cancer   drug resistance   fulvestrant   methylation   oestrogen receptor   promoter  

Dynamic Changes in Estrogen Receptor Alpha (ERα) Promoter Methylation and Drug Resistance in Breast Cancer Cells Background Breast cancer is one of the most common cancers among women worldwide, with approximately 75% of breast cancer patients expressing estrogen receptor alpha (ERα, gene symbol ESR1). ERα is not only an important prognostic marker...

In Vivo Brain Delivery of BBB-Enabled Iduronate 2-Sulfatase in Rats

Medicine, Neurology, Life Sciences, Biochemistry,
blood brain barrier   MPS II   iduronate-2-sulfatase   enzyme replacement therapy   CSF   brain   pharmacokinetics  

Delivery of Enzyme Replacement Therapy Across the Blood-Brain Barrier for Hunter Syndrome Background Hunter syndrome (Mucopolysaccharidosis II, MPS II) is a rare inherited metabolic disorder caused by a deficiency of the iduronate-2-sulfatase (IDS) enzyme. This enzyme deficiency leads to the accumulation of glycosaminoglycans (such as heparan sulfa...

Plasma S100β as a Predictor for Pathology and Cognitive Decline in Alzheimer’s Disease

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Biochemistry,
blood-brain barrier   Alzheimer’s disease   S100β   cognitive decline   biomarker  

Plasma S100β as a Predictor for Pathology and Cognitive Decline in Alzheimer’s Disease Academic Background Alzheimer’s Disease (AD) is the most common form of dementia, characterized by the deposition of β-amyloid (Aβ) plaques and the aggregation of hyperphosphorylated microtubule-associated protein tau (tau). These pathological changes lead to gra...