This study utilized a machine learning framework to explore the underlying cell states and cellular ecosystems constituting soft tissue sarcomas, and associated them with patient prognosis and response to immunotherapy. Research Background: Soft tissue sarcomas are rare and highly heterogeneous malignancies of connective tissues, with limited syste...
In this study, researchers explored the role of the TAK1 activation pathway in CAR T cell therapy-associated immune effector cell-associated neurotoxicity syndrome (ICANS). They established a mouse ICANS model and found that following the transfer of CAR19 T cells, cerebellar cells were activated, underwent morphological changes, and expressed more...
Utilizing Dynamic Single-Cell Analysis to Discover a Clinically Effective Chimeric Antigen Receptor T-Cell Subset for Treating Diffuse Large B-Cell Lymphoma Research Background Chimeric antigen receptor (CAR) T-cell therapy has been proven to be an effective treatment for B-cell malignancies. However, it remains challenging to predict individual cl...
Alzheimer’s disease (AD) is an age-related chronic neurodegenerative disorder, whose pathological mechanism involves multiple factors, including brain inflammation. Microglia, particularly those expressing the AD risk gene TREM2, are believed to play a crucial role in the development of AD, but their exact contribution has not been fully elucidated...
Assessing the Risks of Chemical Exposures for Neurodegenerative Diseases Introduction In recent years, many environmental chemicals, from solvents to pesticides, have been implicated in the development and progression of neurodegenerative diseases. However, a systematic approach akin to genome-wide association studies, which have identified dozens ...
Linking Healthy Neurodevelopment with Imaging, Transcriptomic, and Genetic Associations in Autism Spectrum Disorder and Schizophrenia: A Study of Cortical Gene Expression Patterns Background: How does the complex anatomy and functional organization of the human brain develop from the expression of more than 20,000 genes? And how does this process g...