Mechanism Study on 5-Hydroxytryptamine Regulating Histone Modifications to Drive Liver Metastasis Academic Background Cancer metastasis is one of the leading causes of cancer patient mortality, especially visceral organ metastases such as liver metastasis (liver metastasis). Neuroendocrine tumors (NETs) are a class of highly metastatic tumors, amon...
A Cross-Tissue Transcriptome-Wide Association Study Identifies New Susceptibility Genes for Insomnia Background Insomnia is the second most prevalent psychiatric disorder, affecting nearly one-third of the global population. It not only diminishes quality of life but also increases the risk of cardiovascular diseases, metabolic disorders, mood diso...
Inflammatory Proteins and Hidradenitis Suppurativa: Insights from Genetic Correlation and Mendelian Randomization Studies Research Background Hidradenitis Suppurativa (HS) is a chronic inflammatory skin disease characterized by recurrent nodules, abscesses, and sinus tracts, commonly found in areas of skin friction such as the armpits, groin, peria...
History and Prospects of Nagashima-Type Palmoplantar Keratosis Background Palmoplantar keratoderma (PPK) is a group of hereditary or inflammatory skin disorders characterized by hyperkeratosis of the palms and soles, with diverse clinical manifestations and complex diagnostic criteria. Nagashima-type palmoplantar keratosis (NPPK) is the most common...
Stochastic Modeling of Single-Cell Gene Expression Adaptation Reveals Non-Genomic Contribution to Tumor Subclone Evolution Academic Background Cancer is a complex disease whose progression is driven by the evolution of cells that are selected through adaptive advantages for growth. Traditionally, cancer evolution research has focused primarily on g...
Multimodal Learning Reveals Genotype–Phenotype Dynamics Background The complex relationship between genotype and phenotype has long been a central question in biology. Genotype refers to the genetic information of an organism, while phenotype is the manifestation of this genetic information in a specific environment. Although Wilhelm Johannsen intr...